Jaime de Juan-Sanz
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Explore the profile of Jaime de Juan-Sanz including associated specialties, affiliations and a list of published articles.
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19
Citations
960
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Recent Articles
1.
Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling
Pascual-Caro C, de Juan-Sanz J
PLoS Biol
. 2024 Oct;
22(10):e3002860.
PMID: 39466808
To enable transmission of information in the brain, synaptic vesicles fuse to presynaptic membranes, liberating their content and exposing transiently a myriad of vesicular transmembrane proteins. However, versatile methods for...
2.
Del Prado L, Jaraiz-Rodriguez M, Agro M, Zamora-Dorta M, Azpiazu N, Calleja M, et al.
Nat Commun
. 2024 Oct;
15(1):8682.
PMID: 39375345
Deficiencies in the electron transport chain (ETC) lead to mitochondrial diseases. While mutations are distributed across the organism, cell and tissue sensitivity to ETC disruption varies, and the molecular mechanisms...
3.
Cuhadar U, Calzado-Reyes L, Pascual-Caro C, Aberra A, Ritzau-Jost A, Aggarwal A, et al.
Cell Rep
. 2024 May;
43(5):114186.
PMID: 38700985
The fine control of synaptic function requires robust trans-synaptic molecular interactions. However, it remains poorly understood how trans-synaptic bridges change to reflect the functional states of the synapse. Here, we...
4.
Shen Y, Wen Y, Sposini S, Vishwanath A, Abdelfattah A, Schreiter E, et al.
ACS Sens
. 2023 Jul;
8(8):3014-3022.
PMID: 37481776
Genetically encoded pH sensors based on fluorescent proteins are valuable tools for the imaging of cellular events that are associated with pH changes, such as exocytosis and endocytosis. Superecliptic pHluorin...
5.
Mohylyak I, Bengochea M, Pascual-Caro C, Asfogo N, Fonseca-Topp S, Danda N, et al.
bioRxiv
. 2023 Jun;
PMID: 37333418
During neuronal circuit formation, local control of axonal organelles ensures proper synaptic connectivity. Whether this process is genetically encoded is unclear and if so, its developmental regulatory mechanisms remain to...
6.
de la Rocha-Munoz A, Nunez E, Vishwanath A, Gomez-Lopez S, Dhanasobhon D, Rebola N, et al.
Commun Biol
. 2021 Oct;
4(1):1197.
PMID: 34663888
The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content....
7.
Chen C, Chen B, Wang Y, Curman P, Beilinson H, Brecht R, et al.
J Exp Med
. 2021 May;
218(8).
PMID: 34033676
A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca2+...
8.
Pascual-Caro C, Orantos-Aguilera Y, Sanchez-Lopez I, de Juan-Sanz J, Parys J, Area-Gomez E, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32916960
STIM1 is an endoplasmic reticulum (ER) protein that modulates the activity of a number of Ca transport systems. By direct physical interaction with ORAI1, a plasma membrane Ca channel, STIM1...
9.
Ashrafi G, de Juan-Sanz J, Farrell R, Ryan T
Neuron
. 2019 Dec;
105(4):678-687.e5.
PMID: 31862210
The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP...
10.
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba M, et al.
Neuron
. 2019 Jun;
103(2):217-234.e4.
PMID: 31171447
Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are...