Jacques R Vanfleteren
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Explore the profile of Jacques R Vanfleteren including associated specialties, affiliations and a list of published articles.
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46
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1862
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Recent Articles
1.
De Henau S, Tilleman L, Vangheel M, Luyckx E, Trashin S, Pauwels M, et al.
Nat Commun
. 2015 Dec;
6:8782.
PMID: 26621324
Moderate levels of reactive oxygen species (ROS) are now recognized as redox signalling molecules. However, thus far, only mitochondria and NADPH oxidases have been identified as cellular sources of ROS...
2.
Back P, Matthijssens F, Vanfleteren J, Braeckman B
Anal Biochem
. 2012 Feb;
423(1):147-51.
PMID: 22310498
Because superoxide is involved in various physiological processes, many efforts have been made to improve its accurate quantification. We optimized and validated a superoxide-specific and -sensitive detection method. The protocol...
3.
Back P, De Vos W, Depuydt G, Matthijssens F, Vanfleteren J, Braeckman B
Free Radic Biol Med
. 2012 Jan;
52(5):850-9.
PMID: 22226831
Reactive oxygen species (ROS) are no longer considered merely toxic by-products of the oxidative metabolism. Tightly controlled concentrations of ROS and fluctuations in redox potential may be important mediators of...
4.
Tilleman L, Germani F, De Henau S, Geuens E, Hoogewijs D, Braeckman B, et al.
IUBMB Life
. 2011 Mar;
63(3):166-74.
PMID: 21445847
Extensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene...
5.
Scheckhuber C, Houthoofd K, Weil A, Werner A, De Vreese A, Vanfleteren J, et al.
PLoS One
. 2011 Feb;
6(1):e16620.
PMID: 21305036
The retrograde response constitutes an important signalling pathway from mitochondria to the nucleus which induces several genes to allow compensation of mitochondrial impairments. In the filamentous ascomycete Podospora anserina, an...
6.
Depuydt G, Vanfleteren J, Braeckman B
Adv Exp Med Biol
. 2010 Oct;
694:81-107.
PMID: 20886759
Lifespan of the versatile model system Caenorhabditis elegans can be extended by a decrease of insulin/IGF-1 signaling, TOR signaling, mitochondrial function, protein synthesis and dietary intake. The exact molecular mechanisms...
7.
Schuster E, McElwee J, Tullet J, Doonan R, Matthijssens F, Reece-Hoyes J, et al.
Mol Syst Biol
. 2010 Aug;
6:399.
PMID: 20706209
Insulin/IGF-1 signaling controls metabolism, stress resistance and aging in Caenorhabditis elegans by regulating the activity of the DAF-16/FoxO transcription factor (TF). However, the function of DAF-16 and the topology of...
8.
Brys K, Castelein N, Matthijssens F, Vanfleteren J, Braeckman B
BMC Biol
. 2010 Jun;
8:91.
PMID: 20584279
Background: The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. Results: We found that the...
9.
Back P, Matthijssens F, Vlaeminck C, Braeckman B, Vanfleteren J
Exp Gerontol
. 2010 Jan;
45(7-8):603-10.
PMID: 20096764
Reactive oxygen species have long been considered a major cause of aging. However, previous work showed that loss of superoxide dismutase (SOD) only weakly affects lifespan of Caenorhabditis elegans. Here,...
10.
Braeckman B, Houthoofd K, Vanfleteren J
WormBook
. 2009 Feb;
:1-24.
PMID: 19248207
Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species. We discuss how...