Filip Matthijssens
Overview
Explore the profile of Filip Matthijssens including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1335
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Recent Articles
1.
Demoen L, Matthijssens F, Reunes L, Palhais B, Lintermans B, TSas S, et al.
Sci Adv
. 2024 Nov;
10(44):eado6765.
PMID: 39485844
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Current intensified therapeutic protocols coincide with severe side effects, and no salvage therapy is available for primary therapy-resistant or...
2.
Cardoso B, Duque M, Girio A, Fragoso R, Oliveira M, Allen J, et al.
Haematologica
. 2023 Dec;
109(6):1713-1725.
PMID: 38058200
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on...
3.
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
Wahlen S, Matthijssens F, Van Loocke W, Taveirne S, Kiekens L, Persyn E, et al.
Elife
. 2022 Jul;
11.
PMID: 35793229
Natural killer (NK) cells are innate lymphocytes that eliminate virus-infected and cancer cells by cytotoxicity and cytokine secretion. In addition to circulating NK cells, distinct tissue-resident NK subsets have been...
4.
Pieters T, TSas S, Vanhee S, Almeida A, Driege Y, Roels J, et al.
J Exp Med
. 2021 Aug;
218(10).
PMID: 34406363
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with poor long-term overall survival. Currently, MCL research and development of potential cures is hampered by the lack of good...
5.
Kerselidou D, Dohai B, Nelson D, Daakour S, De Cock N, Al Oula Hassoun Z, et al.
Sci Adv
. 2021 May;
7(19).
PMID: 33962942
The endoplasmic reticulum (ER) is a central eukaryotic organelle with a tubular network made of hairpin proteins linked by hydrolysis of guanosine triphosphate nucleotides. Among posttranslational modifications initiated at the...
6.
Matthijssens F, Sharma N, Nysus M, Nickl C, Kang H, Perez D, et al.
J Clin Invest
. 2021 Feb;
131(6).
PMID: 33555272
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2)...
7.
Van Belle S, El Ashkar S, Cermakova K, Matthijssens F, Goossens S, Canella A, et al.
Cells
. 2021 Jan;
10(1).
PMID: 33477970
HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails...
8.
Loontiens S, Dolens A, Strubbe S, Van de Walle I, Moore F, Depestel L, et al.
Front Cell Dev Biol
. 2020 Nov;
8:599472.
PMID: 33251223
Transcriptional control of hematopoiesis involves complex regulatory networks and functional perturbations in one of these components often results in malignancies. Loss-of-function mutations in , encoding a presumed epigenetic regulator, have...
9.
Roels J, Thenoz M, Szarzynska B, Landfors M, De Coninck S, Demoen L, et al.
Blood Cancer Discov
. 2020 Nov;
1(3):274-289.
PMID: 33179015
Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly...
10.
Pieters T, TSas S, Demoen L, Almeida A, Haenebalcke L, Matthijssens F, et al.
Sci Rep
. 2019 Jul;
9(1):10577.
PMID: 31332244
In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies. Here, we describe an optimized...