Koen Houthoofd
Overview
Explore the profile of Koen Houthoofd including associated specialties, affiliations and a list of published articles.
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23
Citations
1289
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Recent Articles
1.
Scheckhuber C, Houthoofd K, Weil A, Werner A, De Vreese A, Vanfleteren J, et al.
PLoS One
. 2011 Feb;
6(1):e16620.
PMID: 21305036
The retrograde response constitutes an important signalling pathway from mitochondria to the nucleus which induces several genes to allow compensation of mitochondrial impairments. In the filamentous ascomycete Podospora anserina, an...
2.
Braeckman B, Houthoofd K, Vanfleteren J
WormBook
. 2009 Feb;
:1-24.
PMID: 19248207
Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species. We discuss how...
3.
Doonan R, McElwee J, Matthijssens F, Walker G, Houthoofd K, Back P, et al.
Genes Dev
. 2008 Dec;
22(23):3236-41.
PMID: 19056880
The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested...
4.
Hoogewijs D, Houthoofd K, Matthijssens F, Vandesompele J, Vanfleteren J
BMC Mol Biol
. 2008 Jan;
9:9.
PMID: 18211699
Background: In the nematode Caenorhabditis elegans the conserved Ins/IGF-1 signaling pathway regulates many biological processes including life span, stress response, dauer diapause and metabolism. Detection of differentially expressed genes may...
5.
Bass T, Weinkove D, Houthoofd K, Gems D, Partridge L
Mech Ageing Dev
. 2007 Sep;
128(10):546-52.
PMID: 17875315
It was recently reported that the plant polyphenol resveratrol, found, e.g., in grape berry skins, extended lifespan in the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. This...
6.
Houthoofd K, Vanfleteren J
Mol Genet Genomics
. 2007 Mar;
277(6):601-17.
PMID: 17364197
Model organisms have been widely used to study the ageing phenomenon in order to learn about human ageing. Although the phylogenetic diversity between vertebrates and some of the most commonly...
7.
Houthoofd K, Gems D, Johnson T, Vanfleteren J
Interdiscip Top Gerontol
. 2006 Oct;
35:98-114.
PMID: 17063035
The nematode Caenorhabditis elegans has proved to be an excellent model organism for the study of development and aging. Many aging mutants have been discovered in the past two decades,...
8.
Houthoofd K, Vanfleteren J
Exp Gerontol
. 2006 Jun;
41(10):1026-31.
PMID: 16782293
The nematode Caenorhabditis elegans has been subjected to DR by food (Escherichia coli) dilution, growth in axenic medium and using animals having defects in feeding behavior or in specific nutrient...
9.
Burnell A, Houthoofd K, OHanlon K, Vanfleteren J
Exp Gerontol
. 2005 Oct;
40(11):850-6.
PMID: 16221538
When environmental conditions are unsuitable to support nematode reproduction, Caenorhabditis elegans arrests development before the onset of sexual maturity and specialised 'dauer' larvae, adapted for dispersal, and extended diapause are...
10.
Houthoofd K, Johnson T, Vanfleteren J
J Gerontol A Biol Sci Med Sci
. 2005 Sep;
60(9):1125-31.
PMID: 16183950
The first observation of the positive effect of reduced food intake on mammalian life span was made 70 years ago. In the decades that followed, researchers successfully applied this method...