Jacqueline Cherfils
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Explore the profile of Jacqueline Cherfils including associated specialties, affiliations and a list of published articles.
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77
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2964
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Recent Articles
1.
Gambardella A, Liu Y, Bennett M, Green T, Damiano J, Fortunato F, et al.
Epilepsia Open
. 2025 Jan;
PMID: 39806575
Protein-activated kinases mediate spine morphogenesis and synaptic plasticity. PAK3 is part of the p21-activated kinases (PAKs) family of Ras-signaling serine/threonine kinases. Pathogenic variants in the X-linked gene PAK3 have been...
2.
Koduru T, Hantman N, Peters E, Jaworek M, Wang J, Zhang S, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2413100121.
PMID: 39292747
The adenosine di-phosphate (ADP) ribosylation factor (Arf) small guanosine tri-phosphate (GTP)ases function as molecular switches to activate signaling cascades that control membrane organization in eukaryotic cells. In Arf1, the GDP/GTP...
3.
Sartre C, Peurois F, Ley M, Kryszke M, Zhang W, Courilleau D, et al.
Nat Commun
. 2023 Jul;
14(1):4157.
PMID: 37438343
EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal...
4.
5.
Nawrotek A, Dubois P, Zeghouf M, Cherfils J
FEBS Lett
. 2023 Jan;
597(6):778-793.
PMID: 36700390
Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of...
6.
Simanov G, Dang I, Fokin A, Oguievetskaia K, Campanacci V, Cherfils J, et al.
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33923443
During cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To...
7.
Nawrotek A, Cherfils J
Med Sci (Paris)
. 2021 Apr;
37(4):372-378.
PMID: 33908855
mTORC1 is a central player in cell growth, a process that is tightly regulated by the availability of nutrients and that controls various aspects of metabolism in the normal cell...
8.
Nawrotek A, Zeghouf M, Cherfils J
Biochem Soc Trans
. 2020 Dec;
48(6):2721-2728.
PMID: 33336699
Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties are...
9.
Mounier L, Morel A, Ferrandez Y, Morko J, Vaaraniemi J, Gilardone M, et al.
J Med Chem
. 2020 Nov;
63(22):13680-13694.
PMID: 33175535
Osteoporosis is currently treated with drugs targeting the differentiation or viability osteoclasts, the cells responsible for physiological and pathological bone resorption. Nevertheless, osteoporosis drugs that target only osteoclast activity are...
10.
Bekhouche B, Tourville A, Ravichandran Y, Tacine R, Abrami L, Dussiot M, et al.
J Allergy Clin Immunol
. 2020 Apr;
146(5):1201-1204.e8.
PMID: 32283203
No abstract available.