Mahel Zeghouf
Overview
Explore the profile of Mahel Zeghouf including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
1392
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sartre C, Peurois F, Ley M, Kryszke M, Zhang W, Courilleau D, et al.
Nat Commun
. 2023 Jul;
14(1):4157.
PMID: 37438343
EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal...
2.
Nawrotek A, Dubois P, Zeghouf M, Cherfils J
FEBS Lett
. 2023 Jan;
597(6):778-793.
PMID: 36700390
Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of...
3.
Nawrotek A, Zeghouf M, Cherfils J
Biochem Soc Trans
. 2020 Dec;
48(6):2721-2728.
PMID: 33336699
Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties are...
4.
Das S, Malaby A, Nawrotek A, Zhang W, Zeghouf M, Maslen S, et al.
Structure
. 2019 Oct;
27(12):1782-1797.e7.
PMID: 31601460
Membrane dynamic processes require Arf GTPase activation by guanine nucleotide exchange factors (GEFs) with a Sec7 domain. Cytohesin family Arf GEFs function in signaling and cell migration through Arf GTPase...
5.
Nawrotek A, Benabdi S, Niyomchon S, Kryszke M, Ginestier C, Caneque T, et al.
Nat Chem Biol
. 2019 Mar;
15(5):549.
PMID: 30833779
In the version of this article originally published, several co-authors had incorrect affiliation footnote numbers listed in the author list. Tatiana Cañeque and Angelica Mariani should each have affiliation numbers...
6.
Nawrotek A, Benabdi S, Niyomchon S, Kryszke M, Ginestier C, Caneque T, et al.
Nat Chem Biol
. 2019 Feb;
15(4):358-366.
PMID: 30742123
Peripheral membrane proteins orchestrate many physiological and pathological processes, making regulation of their activities by small molecules highly desirable. However, they are often refractory to classical competitive inhibition. Here, we...
7.
Ferrandez Y, Zhang W, Peurois F, Akendengue L, Blangy A, Zeghouf M, et al.
Sci Rep
. 2017 Nov;
7(1):14409.
PMID: 29089502
Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules...
8.
Benabdi S, Peurois F, Nawrotek A, Chikireddy J, Caneque T, Yamori T, et al.
Biochemistry
. 2017 Sep;
56(38):5125-5133.
PMID: 28858527
Arf GTPases and their guanine nucleotide exchange factors (ArfGEFs) are major regulators of membrane traffic and organelle structure in cells. They are associated with a variety of diseases and are...
9.
Peurois F, Veyron S, Ferrandez Y, Ladid I, Benabdi S, Zeghouf M, et al.
Biochem J
. 2017 Feb;
474(7):1259-1272.
PMID: 28196833
Active, GTP-bound small GTPases need to be attached to membranes by post-translational lipid modifications in order to process and propagate information in cells. However, generating and manipulating lipidated GTPases has...
10.
Nawrotek A, Zeghouf M, Cherfils J
Small GTPases
. 2016 Jul;
7(4):283-296.
PMID: 27449855
Arf GTPases assemble protein complexes on membranes to carry out major functions in cellular traffic. An essential step is their activation by guanine nucleotide exchange factors (GEFs), whose Sec7 domain...