Craig R Roy
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Explore the profile of Craig R Roy including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
6607
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Recent Articles
1.
Yang Z, Duncan-Lowey J, Roy C
Infect Immun
. 2025 Mar;
:e0044824.
PMID: 40071978
is a gram-negative, obligate intracellular pathogen that causes human Q fever. Within host cells, proliferates in a spacious, acidic, lysosome-derived -containing vacuole (CCV) by a process that requires the Dot/Icm...
2.
Steiner S, Roy C
mSphere
. 2024 Nov;
9(12):e0052324.
PMID: 39560384
Importance: Understanding the genetic mechanisms that enable to replicate in mammalian host cells has been hampered by the difficulty in making directed mutations. Here, a reliable and efficient system for...
3.
Moss C, Roy C
mBio
. 2024 Oct;
15(11):e0195524.
PMID: 39365064
is an intracellular bacterial pathogen that replicates inside human alveolar macrophages to cause a severe pneumonia known as Legionnaires' disease. requires the Dot/Icm Type IV secretion system to deliver hundreds...
4.
Duncan-Lowey J, Crabill E, Jarret A, Reed S, Roy C
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2217602120.
PMID: 36893270
Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate protective immune responses. In turn, host-adapted pathogens have evolved strategies to modulate these surveillance systems, which can promote dissemination...
5.
Ganesan S, Alvarez N, Steiner S, Fowler K, Corona A, Roy C
mBio
. 2023 Feb;
14(1):e0354522.
PMID: 36728431
There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic...
6.
Park D, Steiner S, Shao M, Roy C, Liu J
Infect Immun
. 2022 Oct;
90(10):e0041022.
PMID: 36190257
Coxiella burnetii is an obligate intracellular bacterial pathogen that has evolved a unique biphasic developmental cycle. The infectious form of C. burnetii is the dormant small cell variant (SCV), which...
7.
Mace K, Meir A, Lukoyanova N, Liu L, Chetrit D, Hospenthal M, et al.
Mol Microbiol
. 2021 Nov;
117(2):307-319.
PMID: 34816517
Legionella pneumophila is an opportunistic pathogen infecting alveolar macrophages and protozoa species. Legionella utilizes a Type IV Secretion System (T4SS) to translocate over 300 effector proteins into its host cell....
8.
Liu L, Roy C
Infect Immun
. 2021 Sep;
89(12):e0026121.
PMID: 34543123
Legionella pneumophila is the causative agent of Legionnaires' disease and is capable of replicating inside phagocytic cells, such as mammalian macrophages. The Dot/Icm type IV secretion system is a L....
9.
Steiner S, Meir A, Roy C
Cell Microbiol
. 2021 Mar;
23(6):e13331.
PMID: 33774901
Coxiella burnetii is a bacterial pathogen that replicates in a specialised lysosome-derived organelle called the Coxiella-containing vacuole (CCV). Establishment of the CCV requires the Dot/Icm type IVB secretion system. A...
10.
Omotade T, Roy C
Infect Immun
. 2020 Jun;
88(8).
PMID: 32482642
Xenophagy targets intracellular pathogens for destruction by the host autophagy pathway. Ubiquitin chains are conjugated to xenophagic targets and recruit multiple autophagy adaptors. The intracellular pathogen resides in a vacuole...