Jim OPrey
Overview
Explore the profile of Jim OPrey including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
2104
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Recent Articles
1.
Baudot A, Wang V, Leach J, OPrey J, Long J, Paulus-Hock V, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2111506119.
PMID: 35737835
Macroautophagy promotes cellular homeostasis by delivering cytoplasmic constituents to lysosomes for degradation [Mizushima, 20, 521-527 (2018)]. However, while most studies have focused on the mechanisms of protein degradation during this...
2.
Koessinger A, Cloix C, Koessinger D, Heiland D, Bock F, Strathdee K, et al.
Cell Death Differ
. 2022 Apr;
29(10):2089-2104.
PMID: 35473984
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour...
3.
Rosenfeldt M, OPrey J, Lindsay C, Nixon C, Roth S, Sansom O, et al.
Cell Death Differ
. 2021 Mar;
28(4):1437-1439.
PMID: 33664481
No abstract available.
4.
Beaumatin F, OPrey J, Barthet V, Zunino B, Parvy J, Bachmann A, et al.
Mol Cell
. 2019 Sep;
76(1):163-176.e8.
PMID: 31492633
Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here...
5.
Riley J, Quarato G, Cloix C, Lopez J, OPrey J, Pearson M, et al.
EMBO J
. 2018 Jul;
37(17).
PMID: 30049712
During apoptosis, pro-apoptotic BAX and BAK are activated, causing mitochondrial outer membrane permeabilisation (MOMP), caspase activation and cell death. However, even in the absence of caspase activity, cells usually die...
6.
Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
Fitzwalter B, Towers C, Sullivan K, Andrysik Z, Hoh M, Ludwig M, et al.
Dev Cell
. 2018 Mar;
44(5):555-565.e3.
PMID: 29533771
Macroautophagy (autophagy) is intimately linked with cell death and allows cells to evade apoptosis. This has prompted clinical trials to combine autophagy inhibitors with other drugs with the aim of...
7.
Mitchell R, Hopcroft L, Baquero P, Allan E, Hewit K, James D, et al.
J Natl Cancer Inst
. 2017 Nov;
110(5):467-478.
PMID: 29165716
Background: Imatinib and second-generation tyrosine kinase inhibitors (TKIs) nilotinib and dasatinib have statistically significantly improved the life expectancy of chronic myeloid leukemia (CML) patients; however, resistance to TKIs remains a...
8.
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, OPrey J, Clark W, et al.
Mol Cell
. 2017 May;
66(4):517-532.e9.
PMID: 28525743
Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that...
9.
Kania E, Pajak B, OPrey J, Gonzalez P, Litwiniuk A, Urbanska K, et al.
FEBS J
. 2017 Mar;
284(9):1370-1387.
PMID: 28342290
Verapamil, an L-type calcium channel blocker, has been used successfully to treat cardiovascular diseases. Interestingly, we have recently shown that treatment of cancer cells with verapamil causes an effect on...
10.
Rosenfeldt M, OPrey J, Flossbach L, Nixon C, Morton J, Sansom O, et al.
Cell Death Differ
. 2017 Jan;
24(7):1303-1304.
PMID: 28106883
No abstract available.