Jun-Ichi Sakamaki
Overview
Explore the profile of Jun-Ichi Sakamaki including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1938
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Recent Articles
1.
Shinoda S, Sakai Y, Matsui T, Uematsu M, Koyama-Honda I, Sakamaki J, et al.
Elife
. 2024 Jun;
12.
PMID: 38831696
During macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the late recruitment of the...
2.
Sakamaki J, Mizushima N
Trends Cell Biol
. 2023 Apr;
33(11):991-1003.
PMID: 37120410
The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins. Although it has long been thought that the substrates of ubiquitination are limited to proteins, recent studies...
3.
Sakamaki J, Mizushima N
Cell Struct Funct
. 2023 Apr;
48(1):99-112.
PMID: 37019684
Protein-lipid conjugation is a widespread modification involved in many biological processes. Various lipids, including fatty acids, isoprenoids, sterols, glycosylphosphatidylinositol, sphingolipids, and phospholipids, are covalently linked with proteins. These modifications direct...
4.
Shimasawa M, Sakamaki J, Maeda T, Mizushima N
J Biol Chem
. 2023 Feb;
299(3):102973.
PMID: 36738789
Although cell size regulation is crucial for cellular functions in a variety of organisms from bacteria to humans, the underlying mechanisms remain elusive. Here, we identify Rim21, a component of...
5.
Sakamaki J, Mizushima N
STAR Protoc
. 2022 Dec;
4(1):101935.
PMID: 36520633
Ubiquitin is covalently conjugated to phospholipids as well as proteins; however, ubiquitinated phospholipids are less abundant than free ubiquitin and ubiquitinated proteins. Here, we describe protocols to purify ubiquitinated phospholipids...
6.
Sakamaki J, Mizushima N
Autophagy
. 2022 Sep;
19(4):1361-1362.
PMID: 36095076
Conjugation of Atg8-family proteins to phosphatidylethanolamine (PE) is important for autophagosome formation. PE conjugation has been thought to be specific to Atg8 among the ubiquitin-family proteins. However, this dogma has...
7.
Sakamaki J, Ode K, Kurikawa Y, Ueda H, Yamamoto H, Mizushima N
Mol Cell
. 2022 Aug;
82(19):3677-3692.e11.
PMID: 36044902
The covalent conjugation of ubiquitin family proteins is a widespread post-translational protein modification. In the ubiquitin family, the ATG8 subfamily is exceptional because it is conjugated mainly to phospholipids. However,...
8.
Iorio C, Rourke J, Wells L, Sakamaki J, Moon E, Hu Q, et al.
Commun Biol
. 2021 Jul;
4(1):907.
PMID: 34302056
Loss of pancreatic β cells is the hallmark of type 1 diabetes, for which provision of insulin is the standard of care. While regenerative and stem cell therapies hold the...
9.
Mimura K, Sakamaki J, Morishita H, Kawazu M, Mano H, Mizushima N
J Biol Chem
. 2021 May;
296:100780.
PMID: 34000301
Macroautophagy (hereafter, autophagy) is a process that directs the degradation of cytoplasmic material in lysosomes. In addition to its homeostatic roles, autophagy undergoes dynamic positive and negative regulation in response...
10.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...