Ivan N Shatsky
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Explore the profile of Ivan N Shatsky including associated specialties, affiliations and a list of published articles.
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45
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1831
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Recent Articles
1.
Andreev D, Shatsky I
Biochemistry (Mosc)
. 2025 Mar;
90(1):32-43.
PMID: 40058972
Recent advances in functional genomics have allowed identification of thousands of translated short open reading frames (sORFs) in the 5' leaders of mammalian mRNA transcripts. While most sORFs are unlikely...
2.
Loughran G, Andreev D, Terenin I, Namy O, Mikl M, Yordanova M, et al.
Nat Struct Mol Biol
. 2025 Mar;
PMID: 40033152
Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizing unconventional mechanisms of eukaryotic translation. These mechanisms include initiation via internal...
3.
Shestakova E, Tumbinsky R, Andreev D, Rozov F, Shatsky I, Terenin I
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38138978
Upstream open reading frames (uORFs) are a frequent feature of eukaryotic mRNAs. Upstream ORFs govern main ORF translation in a variety of ways, but, in a nutshell, they either filter...
4.
Andreev D, Niepmann M, Shatsky I
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555135
The phenomenon of internal initiation of translation was discovered in 1988 on poliovirus mRNA. The prototypic -acting element in the 5' untranslated region (5'UTR) of poliovirus mRNA, which is able...
5.
Shestakova E, Smirnova V, Shatsky I, Terenin I
RNA
. 2022 Dec;
29(3):282-299.
PMID: 36517212
The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over the past two decades, dozens of papers have presented contradictory data on eIF4G2 function. Since its...
6.
Andreev D, Loughran G, Fedorova A, Mikhaylova M, Shatsky I, Baranov P
Genome Biol
. 2022 May;
23(1):111.
PMID: 35534899
Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon...
7.
Smirnova V, Shestakova E, Nogina D, Mishchenko P, Prikazchikova T, Zatsepin T, et al.
Nucleic Acids Res
. 2022 Jan;
50(2):1111-1127.
PMID: 35018467
eIF4G2 (DAP5 or Nat1) is a homologue of the canonical translation initiation factor eIF4G1 in higher eukaryotes but its function remains poorly understood. Unlike eIF4G1, eIF4G2 does not interact with...
8.
Andreev D, Smirnova V, Shatsky I
Biochemistry (Mosc)
. 2021 Sep;
86(9):1095-1106.
PMID: 34565313
Ribosome profiling (riboseq) has opened the possibilities for the genome-wide studies of translation in all living organisms. This method is based on deep sequencing of mRNA fragments protected by the...
9.
Gerresheim G, Hess C, Shalamova L, Fricke M, Marz M, Andreev D, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32971876
Hepatitis C virus (HCV) infects liver cells and often causes chronic infection, also leading to liver cirrhosis and cancer. In the cytoplasm, the viral structural and non-structural (NS) proteins are...
10.
Loughran G, Zhdanov A, Mikhaylova M, Rozov F, Datskevich P, Kovalchuk S, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):24936-24946.
PMID: 32958672
While near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (<10% compared to an AUG in optimal context). Here, we describe a rare case...