William C Merrick
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Explore the profile of William C Merrick including associated specialties, affiliations and a list of published articles.
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61
Citations
3743
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Recent Articles
1.
Merrick W
Mol Cell
. 2025 Jan;
85(1):5-6.
PMID: 39753107
While most of the regulation of translation initiation occurs in the cytosol predominantly through phosphorylation, Ly et al. have discovered the first instance of regulation via protein concentration due to...
2.
Izidoro M, Sokabe M, Villa N, Merrick W, Fraser C
J Biol Chem
. 2022 Aug;
298(10):102368.
PMID: 35963437
During translation initiation, the underlying mechanism by which the eukaryotic initiation factor (eIF) 4E, eIF4A, and eIF4G components of eIF4F coordinate their binding activities to regulate eIF4F binding to mRNA...
3.
Krokowski D, Jobava R, Szkop K, Chen C, Fu X, Venus S, et al.
Cell Rep
. 2022 Jul;
40(3):111092.
PMID: 35858571
The integrated stress response (ISR) plays a pivotal role in adaptation of translation machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation mechanism involving reprogramming of translation via coordinated...
4.
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
Jobava R, Mao Y, Guan B, Hu D, Krokowski D, Chen C, et al.
Mol Cell
. 2021 Oct;
81(20):4191-4208.e8.
PMID: 34686314
To survive, mammalian cells must adapt to environmental challenges. While the cellular response to mild stress has been widely studied, how cells respond to severe stress remains unclear. We show...
5.
Anderson R, Agarwal A, Ghosh A, Guan B, Casteel J, Dvorina N, et al.
FASEB J
. 2021 Oct;
35(11):e21990.
PMID: 34665898
Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation pathways, which affect the translation of only a subset of messenger ribonucleic acid (mRNAs), such...
6.
Komar A, Merrick W
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32192132
Initiation of protein synthesis in eukaryotes is a complex process requiring more than 12 different initiation factors, comprising over 30 polypeptide chains. The functions of many of these factors have...
7.
Chu J, Zhang W, Cencic R, OConnor P, Robert F, Devine W, et al.
Cell Rep
. 2020 Feb;
30(8):2481-2488.e5.
PMID: 32101697
Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this...
8.
Merrick W, Pavitt G
Cold Spring Harb Perspect Biol
. 2018 May;
10(12).
PMID: 29735639
This review summarizes our current understanding of the major pathway for the initiation phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe the major...
9.
Guan B, van Hoef V, Jobava R, Elroy-Stein O, Valasek L, Cargnello M, et al.
Mol Cell
. 2017 Dec;
68(5):885-900.e6.
PMID: 29220654
The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation are followed...
10.
Golovko A, Kojukhov A, Guan B, Morpurgo B, Merrick W, Mazumder B, et al.
Cell Cycle
. 2016 Oct;
15(22):3115-3120.
PMID: 27686860
Eukaryotic initiation factor 2A (eIF2A) is a 65-kDa protein that was first identified in the early 1970s as a factor capable of stimulating initiator methionyl-tRNAi (Met-tRNA) binding to 40S ribosomal...