Irina A Pikuleva
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Explore the profile of Irina A Pikuleva including associated specialties, affiliations and a list of published articles.
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87
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2046
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Recent Articles
1.
Mast N, Butts M, Pikuleva I
J Lipid Res
. 2024 May;
65(6):100555.
PMID: 38719151
Cytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene...
2.
Mast N, Li Y, Pikuleva I
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396919
High dose -efavirenz (EFV) inhibits the HIV reverse transcriptase enzyme and is used to lower HIV load. Low-dose EFV allosterically activates CYP46A1, the key enzyme for cholesterol elimination from the...
3.
El-Darzi N, Mast N, Li Y, Pikuleva I
Cell Mol Life Sci
. 2024 Jan;
81(1):52.
PMID: 38253888
Apolipoprotein B (APOB) is a constituent of unique lipoprotein particles (LPPs) produced in the retinal pigment epithelium (RPE), which separates the neural retina from Bruch's membrane (BrM) and choroidal circulation....
4.
El-Darzi N, Mast N, Li Y, Dailey B, Kang M, Rhee D, et al.
Cell Mol Life Sci
. 2023 Jul;
80(7):194.
PMID: 37392222
Apolipoprotein J (APOJ) is a multifunctional protein with genetic evidence suggesting an association between APOJ polymorphisms and Alzheimer's disease as well as exfoliation glaucoma. Herein we conducted ocular characterizations of...
5.
Mast N, El-Darzi N, Li Y, Pikuleva I
J Lipid Res
. 2023 Jun;
64(7):100401.
PMID: 37330011
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to...
6.
Hammer S, Dorweiler T, McFarland D, Adu-Agyeiwaah Y, Mast N, El-Darzi N, et al.
Diabetologia
. 2023 Jun;
66(9):1705-1718.
PMID: 37311879
Aims/hypothesis: Hyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy, but the nature of these structures remains unknown. Methods: Scanning electron microscopy...
7.
Pikuleva I
Drug Metab Dispos
. 2023 Mar;
51(10):1295-1307.
PMID: 36914277
Of the 57 cytochrome P450 enzymes found in humans, at least 30 have ocular tissues as an expression site. Yet knowledge of the roles of these P450s in the eye...
8.
El-Darzi N, Mast N, Hammer S, Dorweiler T, Busik J, Pikuleva I
J Lipid Res
. 2022 Dec;
64(2):100323.
PMID: 36586438
CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs. 2-Hydroxypropyl-β-cyclodextrin (HPCD), a Food and...
9.
Lerner A, Arnold S, Maxfield E, Koenig A, Toth M, Fortin B, et al.
Alzheimers Res Ther
. 2022 Dec;
14(1):198.
PMID: 36581878
Background: Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by...
10.
Mast N, Li Y, Pikuleva I
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887013
Efavirenz (EFV), an FDA-approved anti-HIV drug, has off-target binding to CYP46A1, the CNS enzyme which converts cholesterol to 24-hydroxycholesterol. At small doses, EFV allosterically activates CYP46A1 in mice and humans...