Ingemar Bjorkhem
Overview
Explore the profile of Ingemar Bjorkhem including associated specialties, affiliations and a list of published articles.
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154
Citations
4521
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Recent Articles
1.
Sennfalt S, Gustavsson P, Malmgren H, Gilland E, Almqvist H, Oscarson M, et al.
J Neurol Sci
. 2024 Apr;
460:123020.
PMID: 38642488
Introduction: Brain calcifications are frequent findings on imaging. In a small proportion of cases, these calcifications are associated with pathogenic gene variants, hence termed primary familial brain calcification (PFBC). The...
2.
Latorre-Leal M, Rodriguez-Rodriguez P, Franchini L, Nikolidakis O, Daniilidou M, Delac L, et al.
Sci Adv
. 2024 Jan;
10(4):eadj1354.
PMID: 38266095
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and reduced levels are observed in Alzheimer's disease (AD). In this study,...
3.
Goikolea J, Latorre-Leal M, Tsagkogianni C, Pikkupeura S, Gulyas B, Cedazo-Minguez A, et al.
J Steroid Biochem Mol Biol
. 2023 Aug;
234:106387.
PMID: 37648096
The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) by the enzyme cytochrome P-450 oxysterol 7α-hydroxylase (Cyp7B1). 27OHC is...
4.
Alanko V, Gaminde-Blasco A, Quintela-Lopez T, Loera-Valencia R, Solomon A, Bjorkhem I, et al.
Glia
. 2023 Feb;
71(6):1414-1428.
PMID: 36779429
Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases since unlike peripheral cholesterol, 27-OH is transported across the blood-brain barrier. However, the effects of high...
5.
Porru E, Edstrom E, Arvidsson L, Elmi-Terander A, Fletcher-Sandersjoo A, Sandblom A, et al.
Brain Sci
. 2022 Nov;
12(11).
PMID: 36358376
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt....
6.
Loera-Valencia R, Ismail M, Goikolea J, Lodeiro M, Mateos L, Bjorkhem I, et al.
Mol Neurobiol
. 2021 Aug;
58(12):6063-6076.
PMID: 34449045
Alterations in cholesterol metabolism in the brain have a major role in the physiology of Alzheimer's disease (AD). Oxysterols are cholesterol metabolites with multiple implications in memory functions and in...
7.
Bountouvi E, Giorgi M, Papadopoulou A, Blennow K, Bjorkhem I, Tsirouda M, et al.
Innov Clin Neurosci
. 2021 Jun;
18(1-3):11-16.
PMID: 34150357
Niemann-Pick Type C disease (NPC) is a rare, incurable, autosomal-recessive, lysosomal storage disorder with protean and progressive neurovisceral manifestations characterized by accumulation of intracellular unesterified cholesterol. The investigational use of...
8.
Pedrelli M, Parini P, Kindberg J, Arnemo J, Bjorkhem I, Aasa U, et al.
J Lipid Res
. 2021 Mar;
62:100065.
PMID: 33713671
Plasma cholesterol and triglyceride (TG) levels are twice as high in hibernating brown bears (Ursus arctos) than healthy humans. Yet, bears display no signs of early stage atherosclerosis development when...
9.
Sandebring-Matton A, Goikolea J, Bjorkhem I, Paternain L, Kemppainen N, Laatikainen T, et al.
Alzheimers Res Ther
. 2021 Mar;
13(1):56.
PMID: 33676572
Background: 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer's disease (AD), has not been investigated previously in relation to cognition...
10.
Parrado-Fernandez C, Leoni V, Saeed A, Rodriguez-Rodriguez P, Sandebring-Matton A, Cordoba-Beldad C, et al.
Br J Pharmacol
. 2020 Dec;
178(16):3194-3204.
PMID: 33345295
Background And Purpose: The cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood-brain barrier (BBB). Recently, we reported that QAlb is lower in females....