Aicha Saadane
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Explore the profile of Aicha Saadane including associated specialties, affiliations and a list of published articles.
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26
Citations
590
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Recent Articles
1.
Bandara S, Saadane A, Shen T, Yakovleva D, Banerjee R, Zhang Y, et al.
J Lipid Res
. 2025 Feb;
66(3):100758.
PMID: 39971162
Carotenoids, essential nutrients for eye health, are absorbed in the intestine to support vitamin A homeostasis and provide cellular protection. This process involves the lipid transporters scavenger receptor class B...
2.
Luu J, Saadane A, Leinonen H, Choi E, Gao F, Lewandowski D, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2221045120.
PMID: 37126699
Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from genetic and environmental perturbations of cellular and tissue homeostasis. These disruptions accumulate with...
3.
Saadane A, Veenstra A, Minns M, Tang J, Du Y, Abubakr Elghazali F, et al.
Diabetologia
. 2023 Jan;
66(3):590-602.
PMID: 36698021
Aims/hypothesis: Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes...
4.
Lessieur E, Liu H, Saadane A, Du Y, Kiser J, Kern T
Diabetologia
. 2022 Jul;
65(10):1734-1744.
PMID: 35852587
Aims/hypothesis: Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microvascular diseases such as diabetic retinopathy. Lesions of diabetic retinopathy are unique to the...
5.
El-Darzi N, Mast N, Buchner D, Saadane A, Dailey B, Trichonas G, et al.
Front Pharmacol
. 2022 Jun;
13:902254.
PMID: 35721135
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer's disease...
6.
Lessieur E, Liu H, Saadane A, Du Y, Tang J, Kiser J, et al.
Invest Ophthalmol Vis Sci
. 2021 Oct;
62(13):7.
PMID: 34643662
Purpose: Previous studies indicate that leukocytes, notably neutrophils, play a causal role in the capillary degeneration observed in diabetic retinopathy (DR), however, the mechanism by which they cause such degeneration...
7.
Saadane A, Du Y, Thoreson W, Miyagi M, Lessieur E, Kiser J, et al.
Am J Pathol
. 2021 Jul;
191(10):1805-1821.
PMID: 34214506
This study tested the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca-sensitive protease, calpain, resulting in oxidative stress and inflammation,...
8.
Berkowitz B, Podolsky R, Childers K, Saadane A, Kern T, Roberts R, et al.
PLoS One
. 2021 Mar;
16(3):e0245161.
PMID: 33661941
Purpose: The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we...
9.
Saadane A, Lessieur E, Du Y, Liu H, Kern T
PLoS One
. 2020 Sep;
15(9):e0238727.
PMID: 32941450
Purpose: Female mice have been found to be resistant to streptozotocin (STZ)-induced diabetes, and pre-clinical research related to diabetic complications commonly omits females. The purpose of this study was to...
10.
El-Darzi N, Mast N, Petrov A, Dao T, Astafev A, Saadane A, et al.
Cell Mol Life Sci
. 2020 May;
78(3):963-983.
PMID: 32440710
Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport....