Ingrid Jordens
Overview
Explore the profile of Ingrid Jordens including associated specialties, affiliations and a list of published articles.
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21
Citations
1562
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Recent Articles
1.
Bugter J, van Kerkhof P, Jordens I, Janssen E, Minh T, Iglesias van Montfort D, et al.
Life Sci Alliance
. 2024 Jul;
7(9).
PMID: 38969364
The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for WNT. Loss-of-function mutations in...
2.
Colozza G, Lee H, Merenda A, Wu S, Catala-Bordes A, Radaszkiewicz T, et al.
Sci Adv
. 2023 Nov;
9(47):eadh9673.
PMID: 38000028
The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom. Paneth cells form a major element of the niche microenvironment...
3.
van Kerkhof P, Kralj T, Spanevello F, van Bloois L, Jordens I, van der Vaart J, et al.
J Control Release
. 2023 Feb;
356:72-83.
PMID: 36813038
The transmembrane receptor LGR5 potentiates Wnt/β-catenin signaling by binding both secreted R-spondin (RSPOs) and the Wnt tumor suppressors RNF43/ZNRF3, directing clearance of RNF43/ZNRF3 from the cell surface. Besides being widely...
4.
Spit M, Fenderico N, Jordens I, Radaszkiewicz T, Lindeboom R, Bugter J, et al.
EMBO J
. 2020 Sep;
39(18):e103932.
PMID: 32965059
Wnt/β-catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the...
5.
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati G, McKenna J, et al.
Elife
. 2020 May;
9.
PMID: 32432544
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs)...
6.
Stanganello E, Zahavi E, Burute M, Smits J, Jordens I, Maurice M, et al.
iScience
. 2019 Mar;
13:318-327.
PMID: 30878878
The establishment of neuronal polarity is driven by cytoskeletal remodeling that stabilizes and promotes the growth of a single axon from one of the multiple neurites. The importance of the...
7.
Fenderico N, van Scherpenzeel R, Goldflam M, Proverbio D, Jordens I, Kralj T, et al.
Nat Commun
. 2019 Jan;
10(1):365.
PMID: 30664649
Wnt-induced β-catenin-mediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis. Enhanced Wnt receptor expression due to mutational inactivation of the ubiquitin ligases RNF43/ZNRF3 recently emerged...
8.
Gerlach J, Jordens I, Tauriello D, van t Land-Kuper I, Bugter J, Noordstra I, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(17):E3996-E4005.
PMID: 29632210
Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the...
9.
Kievit A, Tessadori F, Douben H, Jordens I, Maurice M, Hoogeboom J, et al.
Eur J Hum Genet
. 2018 Jan;
26(2):210-219.
PMID: 29348693
Blepharocheilodontic syndrome (BCDS) consists of lagophthalmia, ectropion of the lower eyelids, distichiasis, euryblepharon, cleft lip/palate and dental anomalies and has autosomal dominant inheritance with variable expression. We identified heterozygous variants...
10.
Anvarian Z, Nojima H, van Kappel E, Madl T, Spit M, Viertler M, et al.
Nat Struct Mol Biol
. 2016 Mar;
23(4):324-32.
PMID: 26974125
Signaling cascades depend on scaffold proteins that regulate the assembly of multiprotein complexes. Missense mutations in scaffold proteins are frequent in human cancer, but their relevance and mode of action...