Lennert Janssen
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Explore the profile of Lennert Janssen including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
2351
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Recent Articles
1.
Stevenin V, Coipan C, Duijster J, van Elsland D, Voogd L, Bigey L, et al.
Cell Rep
. 2024 Nov;
43(11):114931.
PMID: 39488829
Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonella induces cell transformation, we performed multi-omics and phenotypic analyses of Salmonella clinical strains isolated from patients later...
2.
Jongsma M, Bakker N, Voortman L, Koning R, Bos E, Akkermans J, et al.
Curr Biol
. 2024 Sep;
34(19):4476-4494.e11.
PMID: 39276769
Kinesin and dynein-dynactin motors move endosomes and other vesicles bidirectionally along microtubules, a process mainly studied under in vitro conditions. Here, we provide a physiological bidirectional transport model following color-coded,...
3.
Qiao X, van der Zanden S, Li X, Tan M, Zhang Y, Song J, et al.
Mol Cancer
. 2024 Jun;
23(1):120.
PMID: 38831402
The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin and idarubicin, remains almost unmatched in oncology, despite a side effect profile including cumulative dose-dependent cardiotoxicity, therapy-related...
4.
Perrin P, Janssen L, Janssen H, van den Broek B, Voortman L, van Elsland D, et al.
Curr Biol
. 2021 Jul;
31(17):3884-3893.e4.
PMID: 34237268
The endosomal system constitutes a highly dynamic vesicle network used to relay materials and signals between the cell and its environment. Once internalized, endosomes gradually mature into late acidic compartments...
5.
Jongsma M, de Waard A, Raaben M, Zhang T, Cabukusta B, Platzer R, et al.
Immunity
. 2021 Feb;
54(2):387.
PMID: 33567263
No abstract available.
6.
Jongsma M, de Waard A, Raaben M, Zhang T, Cabukusta B, Platzer R, et al.
Immunity
. 2020 Dec;
54(1):132-150.e9.
PMID: 33271119
HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8 T cells. This process is often hijacked by tumors and pathogens for immune evasion. Because options...
7.
Margiotta A, Frei D, Sendstad I, Janssen L, Neefjes J, Bakke O
J Cell Sci
. 2020 Sep;
133(19).
PMID: 32907852
The invariant chain (Ii, also known as CD74) is a multifunctional regulator of adaptive immune responses and is responsible for sorting major histocompatibility complex class I and class II (MHCI...
8.
Jongsma M, Bakker J, Cabukusta B, Liv N, van Elsland D, Fermie J, et al.
EMBO J
. 2020 Feb;
39(6):e102301.
PMID: 32080880
The endolysosomal system fulfils a myriad of cellular functions predicated on regulated membrane identity progressions, collectively termed maturation. Mature or "late" endosomes are designated by small membrane-bound GTPases Rab7 and...
9.
Jongsma M, Berlin I, Wijdeven R, Janssen L, Janssen G, Garstka M, et al.
Cell
. 2016 Jul;
166(1):152-66.
PMID: 27368102
Through a network of progressively maturing vesicles, the endosomal system connects the cell's interior with extracellular space. Intriguingly, this network exhibits a bilateral architecture, comprised of a relatively immobile perinuclear...
10.
Wijdeven R, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, et al.
Nat Commun
. 2016 Jun;
7:11808.
PMID: 27283760
Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors...