Peter van Kerkhof
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Explore the profile of Peter van Kerkhof including associated specialties, affiliations and a list of published articles.
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21
Citations
512
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Recent Articles
1.
Bugter J, van Kerkhof P, Jordens I, Janssen E, Minh T, Iglesias van Montfort D, et al.
Life Sci Alliance
. 2024 Jul;
7(9).
PMID: 38969364
The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for WNT. Loss-of-function mutations in...
2.
van Kerkhof P, Kralj T, Spanevello F, van Bloois L, Jordens I, van der Vaart J, et al.
J Control Release
. 2023 Feb;
356:72-83.
PMID: 36813038
The transmembrane receptor LGR5 potentiates Wnt/β-catenin signaling by binding both secreted R-spondin (RSPOs) and the Wnt tumor suppressors RNF43/ZNRF3, directing clearance of RNF43/ZNRF3 from the cell surface. Besides being widely...
3.
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati G, McKenna J, et al.
Elife
. 2020 May;
9.
PMID: 32432544
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs)...
4.
van der Sluijs P, Zibouche M, van Kerkhof P
Front Immunol
. 2013 Dec;
4:359.
PMID: 24302923
Natural Killer cells are a subset of cytotoxic lymphocytes that are important in host defense against infections and transformed cells. They exert this function through recognition of target cells by...
5.
Hassink G, Slotman J, Oorschot V, van der Reijden B, Monteferrario D, Noordermeer S, et al.
Biol Open
. 2012 Dec;
1(6):607-14.
PMID: 23213454
The ubiquitin system plays an important role in trafficking of signaling receptors from the plasma membrane to lysosomes. Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains...
6.
Slotman J, da Silva Almeida A, Hassink G, van de Ven R, van Kerkhof P, Kuiken H, et al.
J Biol Chem
. 2012 Mar;
287(19):15533-43.
PMID: 22433856
Growth hormone receptor (GHR) endocytosis is a highly regulated process that depends on the binding and activity of the multimeric ubiquitin ligase, SCF(βTrCP) (Skp Cullin F-box). Despite a specific interaction...
7.
Elstak E, Te Loo M, Tesselaar K, van Kerkhof P, Loeffen J, Grivas D, et al.
Pediatr Blood Cancer
. 2011 Jul;
58(4):598-605.
PMID: 21755595
Background: UNC13D, encoding the protein munc13-4, is essential in intracellular trafficking and exocytosis of lytic granules. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3 (FHL3), a...
8.
Putters J, da Silva Almeida A, van Kerkhof P, van Rossum A, Gracanin A, Strous G
PLoS One
. 2011 Feb;
6(2):e14676.
PMID: 21347402
Background: Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP). In several instances, Janus kinase...
9.
van Kerkhof P, Westgeest M, Hassink G, Strous G
Exp Cell Res
. 2011 Jan;
317(7):1071-82.
PMID: 21195069
The ubiquitin ligase SCF(TrCP) is required for internalisation of the growth hormone receptor (GHR) and acts via a direct interaction with the ubiquitin-dependent endocytosis motif. Details of how the ligase...
10.
Donoso M, Cancino J, Lee J, van Kerkhof P, Retamal C, Bu G, et al.
Mol Biol Cell
. 2008 Nov;
20(1):481-97.
PMID: 19005208
Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic recycling receptor with two cytoplasmic tyrosine-based basolateral sorting signals. Here we show that during biosynthetic trafficking LRP1 uses AP1B adaptor complex...