Ian J Majewski
Overview
Explore the profile of Ian J Majewski including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
2972
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Recent Articles
1.
Xu Z, Flensburg C, Bilardi R, Majewski I
Nucleic Acids Res
. 2023 Nov;
51(22):12031-12042.
PMID: 37953355
Molnupiravir (EIDD-2801) is an antiviral that received approval for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Treatment of bacteria or cell lines with the active form...
2.
Abdulla H, Alserihi R, Flensburg C, Abeysekera W, Luo M, Gray D, et al.
J Exp Med
. 2023 Mar;
220(6).
PMID: 36920307
Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show that the oncogenic transcription factor Lmo2 causes autonomous...
3.
Fang H, Yan H, Bilardi R, Flensburg C, Yang H, Barbour J, et al.
Genome Med
. 2022 Nov;
14(1):124.
PMID: 36316687
Background: Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and treatment of cytomegalovirus. It has long been considered a mutagen and carcinogen....
4.
Thijssen R, Tian L, Anderson M, Flensburg C, Jarratt A, Garnham A, et al.
Blood
. 2022 Jun;
140(20):2127-2141.
PMID: 35709339
Venetoclax (VEN) inhibits the prosurvival protein BCL2 to induce apoptosis and is a standard therapy for chronic lymphocytic leukemia (CLL), delivering high complete remission rates and prolonged progression-free survival in...
5.
Schmidt B, Brown L, Ryland G, Lonsdale A, Kosasih H, Ludlow L, et al.
Blood Adv
. 2022 Apr;
6(14):4093-4097.
PMID: 35482550
No abstract available.
6.
Palles C, West H, Chew E, Galavotti S, Flensburg C, Grolleman J, et al.
Am J Hum Genet
. 2022 Apr;
109(5):953-960.
PMID: 35460607
We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4. We identified five individuals with bi-allelic MBD4...
7.
Cmero M, Schmidt B, Majewski I, Ekert P, Oshlack A, Davidson N
Genome Biol
. 2021 Oct;
22(1):296.
PMID: 34686194
Calling fusion genes from RNA-seq data is well established, but other transcriptional variants are difficult to detect using existing approaches. To identify all types of variants in transcriptomes we developed...
8.
9.
Flensburg C, Oshlack A, Majewski I
Bioinformatics
. 2021 Jun;
37(22):4023-4032.
PMID: 34132781
Motivation: Calling copy number alterations (CNAs) from RNA sequencing (RNA-Seq) is challenging, because of the marked variability in coverage across genes and paucity of single nucleotide polymorphisms (SNPs). We have...
10.
Xu Z, Vandenberg C, Lieschke E, Di Rago L, Scott C, Majewski I
Mol Cancer Res
. 2021 Apr;
19(8):1350-1360.
PMID: 33863812
Patients with cancer treated with PARP inhibitors (PARPi) experience various side effects, with hematologic toxicity being most common. Short-term treatment of mice with olaparib resulted in depletion of reticulocytes, B-cell...