Hussein N Yassine
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Explore the profile of Hussein N Yassine including associated specialties, affiliations and a list of published articles.
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69
Citations
1043
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Recent Articles
1.
Wang S, Li B, Li J, Cai Z, Hugo C, Sun Y, et al.
Mol Neurodegener
. 2025 Feb;
20(1):15.
PMID: 39901180
Background: Cellular senescence, a hallmark of aging, has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully...
2.
Nedelkov D, Tsokolas Z, Rodrigues M, Sible I, Han S, Kerman B, et al.
bioRxiv
. 2025 Jan;
PMID: 39763949
The apolipoprotein E ( ) ε4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet...
3.
Hugo C, Asante I, Sadybekov A, Katritch V, Yassine H
Antioxid Redox Signal
. 2024 Nov;
41(16-18):1100-1116.
PMID: 39575710
Cellular senescence is a critical process underlying aging and is associated with age-related diseases such as Alzheimer's disease. Lipids are implicated in cellular senescence. Fatty acids, particularly eicosanoids, have been...
4.
Urich T, Tsiknia A, Ali N, Park J, Mack W, Cortessis V, et al.
Nutr Rev
. 2024 Nov;
PMID: 39499795
Context: Carrying the apolipoprotein ε4 allele (APOE ε4) is the strongest genetic risk factor for late-onset Alzheimer's disease. There is some evidence suggesting that APOE ε4 may modulate the influence...
5.
Yassine H, Carrasco A, Badie D
J Alzheimers Dis
. 2024 Oct;
101(s1):S455-S466.
PMID: 39422948
Background: Epidemiology cohorts reveal associations between levels or intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) and a lower risk of Alzheimer's disease (AD). However, the results of randomized clinical...
6.
Kloske C, Belloy M, Blue E, Bowman G, Carrillo M, Chen X, et al.
Alzheimers Dement
. 2024 Jul;
20(9):6590-6605.
PMID: 39031528
Introduction: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta...
7.
Vaidya D, Yeboah-Kordieh Y, Howard M, Hugenschmidt C, Nyquist P, Michos E, et al.
Res Sq
. 2024 May;
PMID: 38746210
Background: Females have greater brain volume and cerebral blood flow than males when controlling for intracranial volume and age. Brain volume decreases after menopause, suggesting a role of sex hormones....
8.
Ebright B, Duro M, Chen K, Louie S, Yassine H
Trends Endocrinol Metab
. 2024 Apr;
35(8):745-757.
PMID: 38609814
Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural...
9.
Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?
Kerman B, Self W, Yassine H
Curr Opin Clin Nutr Metab Care
. 2024 Jan;
27(2):116-124.
PMID: 38170690
Purpose Of Review: Most omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation clinical trials report inconsistent or null findings on measures of cognition or Alzheimer's disease (AD) with a relatively large...
10.
Duro M, Van Valkenburgh J, Ingles D, Tran J, Cai Z, Ebright B, et al.
ACS Chem Neurosci
. 2023 Dec;
14(24):4409-4418.
PMID: 38048230
Docosahexaenoic acid [22:6(-3), DHA], a polyunsaturated fatty acid, has an important role in regulating neuronal functions and in normal brain development. Dysregulated brain DHA uptake and metabolism are found in...