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Dobrin Nedelkov

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Articles 74
Citations 931
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Recent Articles
1.
Nedelkov D, Tsokolas Z, Rodrigues M, Sible I, Han S, Kerman B, et al.
bioRxiv . 2025 Jan; PMID: 39763949
The apolipoprotein E ( ) ε4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet...
2.
Koska J, Hu Y, Furtado J, Billheimer D, Nedelkov D, Schwenke D, et al.
Diabetes Care . 2024 Oct; 47(12):2214-2222. PMID: 39453822
Objective: Higher truncated-to-native apolipoprotein (apo) C-I proteoform ratios (C-I'/C-I) are associated with favorable cardiometabolic risk profiles, but their relationship with longitudinal changes in insulin resistance (IR) and incident diabetes is...
3.
Koska J, Hansen S, Hu Y, Jensen M, Billheimer D, Nedelkov D, et al.
Atherosclerosis . 2024 Jun; 395:117584. PMID: 38823352
Background And Aims: Apolipoprotein C-III (apoC-III) proteoform composition shows distinct relationships with plasma lipids and cardiovascular risk. The present study tested whether apoC-III proteoforms are associated with risk of peripheral...
4.
Koska J, Hu Y, Furtado J, Billheimer D, Nedelkov D, Allison M, et al.
Atherosclerosis . 2023 Aug; 380:117214. PMID: 37573768
Background And Aims: Higher truncated-to-native proteoform ratios of apolipoproteins (apo) C-I (C-I'/C-I) and C-II (C-II'/C-II) are associated with less atherogenic lipid profiles. We examined prospective relationships of C-I'/C-II and C-II'/C-II...
5.
Sinari S, Koska J, Hu Y, Furtado J, Jensen M, Budoff M, et al.
Arterioscler Thromb Vasc Biol . 2023 Jun; 43(8):1560-1571. PMID: 37317850
Background: Apo CIII (apolipoprotein CIII) is an important regulator of triglyceride metabolism and was associated with cardiovascular risk in several cohorts. It is present in 4 major proteoforms, a native...
6.
Meuret C, Hu Y, Smadi S, Bantugan M, Xian H, Martinez A, et al.
Alzheimers Res Ther . 2023 May; 15(1):96. PMID: 37221560
Carrying the apolipoprotein E (ApoE) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset Alzheimer's disease, but the degree to which apoE glycosylation affects its development...
7.
Trenchevska O, Koska J, Sinari S, Yassine H, Reaven P, Billheimer D, et al.
Clin Mass Spectrom . 2023 Feb; 1:27-31. PMID: 36778895
Background: Cystatin C (CysC), a marker for chronic kidney disease, exists as three sequence proteoforms, in addition to the wild-type sequence: one contains hydroxyproline at position 3 (3Pro-OH), the two...
8.
Koska J, Furtado J, Hu Y, Sinari S, Budoff M, Billheimer D, et al.
J Lipid Res . 2022 Aug; 63(9):100263. PMID: 35952903
Apolipoproteins (apo) C-I and C-II are key regulators of triglyceride and HDL metabolism. Both exist as full-size native and truncated (apoC-I'; apoC-II') posttranslational proteoforms. However, the determinants and the role...
9.
Prokaeva T, Joshi T, Klimtchuk E, Gibson V, Spencer B, Siddiqi O, et al.
Amyloid . 2022 May; 29(4):255-262. PMID: 35575118
Background: β2-microglobulin amyloidosis was first described in the 1980s as a protein deposition disease associated with long-term haemodialysis. More recently, two inherited forms resulting from separate point mutations in the...
10.
Hu Y, Meuret C, Martinez A, Yassine H, Nedelkov D
J Lipid Res . 2021 Feb; 62:100014. PMID: 33518512
Apolipoproteins C-I, C-II, and C-III interact with ApoE to regulate lipoprotein metabolism and contribute to Alzheimer's disease pathophysiology. In plasma, apoC-I and C-II exist as truncated isoforms, while apoC-III exhibits...