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Hussein N Yassine

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Articles 69
Citations 1043
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Recent Articles
11.
Rhea E, Leclerc M, Yassine H, Capuano A, Tong H, Petyuk V, et al.
Aging Dis . 2023 Aug; 15(4):1688-1725. PMID: 37611907
Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with devastating public health consequences. While peripheral insulin resistance is a key feature of most forms of T2DM...
12.
Meuret C, Hu Y, Smadi S, Bantugan M, Xian H, Martinez A, et al.
Alzheimers Res Ther . 2023 May; 15(1):96. PMID: 37221560
Carrying the apolipoprotein E (ApoE) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset Alzheimer's disease, but the degree to which apoE glycosylation affects its development...
13.
Bantugan M, Xian H, Solomon V, Lee M, Cai Z, Wang S, et al.
J Lipid Res . 2023 Mar; 64(6):100354. PMID: 36958720
Apolipoprotein ε allele 4 (APOE4) influences the metabolism of polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA). The entorhinal cortex (EC) in the brain is affected early in Alzheimer's...
14.
Yassine H, Self W, Kerman B, Santoni G, Navalpur Shanmugam N, Abdullah L, et al.
Alzheimers Dement . 2022 Dec; 19(3):1041-1066. PMID: 36479795
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with...
15.
Huguenard C, Cseresznye A, Evans J, Darcey T, Nkiliza A, Keegan A, et al.
Curr Res Transl Med . 2022 Nov; 71(1):103362. PMID: 36436355
Background: The apolipoprotein E (APOE) ε4 allele, involved in fatty acid (FA) metabolism, is a major genetic risk factor for Alzheimer's disease (AD). This study examined the influence of APOE...
16.
Nazarian A, Loiko E, Yassine H, Finch C, Kulminski A
Front Aging Neurosci . 2022 Nov; 14:1023493. PMID: 36389057
The ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We examined whether these alleles modulated associations of 94 single-nucleotide polymorphisms (SNPs) harbored by 26 genes in...
17.
Van Valkenburgh J, Duro M, Burnham E, Chen Q, Wang S, Tran J, et al.
Prostaglandins Leukot Essent Fatty Acids . 2022 Nov; 186:102510. PMID: 36341886
Dysreglulated brain arachidonic acid (AA) metabolism is involved in chronic inflammation and is influenced by apolipoprotein E4 (APOE4) genotype, the strongest genetic risk factor of late-onset Alzheimer's disease (AD). Visualization...
18.
Yassine H
Am J Clin Nutr . 2022 Oct; 116(6):1474-1475. PMID: 36253954
No abstract available.
19.
Ebright B, Assante I, Poblete R, Wang S, Duro M, Bennett D, et al.
Alzheimers Res Ther . 2022 Oct; 14(1):152. PMID: 36217192
Background: Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer's disease (AD) dementia pathogenesis. Carrying the apolipoprotein ε4 (APOE4) allele has been associated with an accentuated response to brain...
20.
Asante I, Louie S, Yassine H
Ann N Y Acad Sci . 2022 Oct; 1518(1):84-105. PMID: 36200578
A chronic state of unresolved inflammation in Alzheimer's disease (AD) is intrinsically involved with the remodeling of brain lipids. This review highlights the effect of carrying the apolipoprotein E ε4...