Hu-Ri Piao
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Explore the profile of Hu-Ri Piao including associated specialties, affiliations and a list of published articles.
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80
Citations
475
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Recent Articles
1.
Gao Y, Li M, Wang D, Jin S, Ma X, Jin X, et al.
Chem Biol Drug Des
. 2024 Dec;
104(6):e70024.
PMID: 39702874
Nuclear factor κB (NF-κB) is a key inducible transcription factor that controls a large number of genes involved in inflammatory and immune processes. The entire inflammation-mediated process uses NF-κB as...
2.
Ma X, Li M, Jin K, Han Z, Gao Y, Jin X, et al.
Chem Biodivers
. 2024 Aug;
21(12):e202401542.
PMID: 39193815
The hypoxia-inducible factor-1α (HIF-1α) pathway has been implicated in tumor angiogenesis, growth, and metastasis. Therefore, the inhibition of this pathway is an important therapeutic target for cancer. Thiazole derivatives have...
3.
Lu Y, Liu C, Ma J, Piao H, Zhang C, Jin X, et al.
Fitoterapia
. 2024 Jun;
177:106052.
PMID: 38848978
Hypoxia-inducing factor-1α (HIF-1α) is overexpressed in variety of tumor patients and plays an important role in the regulation of hypoxia response in tumor cells. Therefore, its inhibitors have become one...
4.
Zhang L, Li M, Wang D, Jin X, Chen F, Piao H
Molecules
. 2022 Nov;
27(22).
PMID: 36432026
(1) Background: Nuclear factor κB (NF-κB) is an important transcriptional regulator that regulates the inflammatory pathway and plays a key role in cellular inflammatory and immune responses. The presence of...
5.
Zhao L, Wang S, Pannecouque C, De Clercq E, Piao H, Chen F
Eur J Med Chem
. 2022 Jul;
240:114581.
PMID: 35797898
Adding to past success in developing non-nucleoside reverse transcriptase inhibitors (NNRTIs), we report herein our efforts to optimize an FDA-approved NNRTI, doravirine, into a series of novel biphenyl-substituted pyridone derivatives....
6.
Jin X, Piao H, Pannecouque C, De Clercq E, Zhuang C, Chen F
Eur J Med Chem
. 2021 Sep;
226:113868.
PMID: 34583311
A series of novel naphthyl-diarylpyrimidine (DAPY) derivatives were designed and synthesized to explore the entrance channel of the non-nucleoside reverse transcriptase inhibitors binding pocket (NNIBP) by incorporating different flexible side...
7.
Zhao L, Guo F, Wang H, Dou T, Da Qi J, Xu W, et al.
Med Chem
. 2021 Jun;
18(4):509-520.
PMID: 34182915
Background: TGF-β signaling pathway inhibition is considered an effective way to prevent the development of several diseases. In the design and synthesis of TGF-β inhibitors, a rhodanine compound containing a...
8.
Guo F, Zheng C, Wang M, Ai J, Ying Han L, Yang L, et al.
ChemMedChem
. 2021 Mar;
16(15):2354-2365.
PMID: 33738962
Three series of new imidazole-fused imidazo[2,1-b][1,3,4]thiadiazole analogues (compounds 20 a-g, 21 a-g, and 22 a-g) have been synthesized, and their antibacterial and antifungal activities have been evaluated. All the target...
9.
Liu Y, Guo Z, Wang J, Wang H, Da Qi J, Ma J, et al.
Eur J Med Chem
. 2021 Mar;
216:113311.
PMID: 33677350
Drugs of targeting both activin receptor-like kinase 5 (ALK5) and p38α have therapeutic advantages, making them attractive treatment options for tumors. Two series of 4-(1H-indazol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazoles 13a-g and 4-(1-methyl-1H-indazol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazoles 20a-g were...
10.
Li X, Cui X, Zhou S, Xing D, Piao H, Zhang Q, et al.
Chem Biol Interact
. 2021 Mar;
339:109430.
PMID: 33676887
Connexin-40 (Cx40) and Cx43 are the principal components of gap junctions. Dysregulation of connexin expression is clinically related to cardiac pathologies. 25-Hydroxy protopanaxadiol [25-OH-PPD, 20 (R)-dammarane-3β, 12β, 20, 25-tetrol], known...