Hiroki Sasaguri
Overview
Explore the profile of Hiroki Sasaguri including associated specialties, affiliations and a list of published articles.
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35
Citations
1497
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Recent Articles
1.
Morito T, Watamura N, Sasaguri H, Tomita T, Higuchi M, Okano H, et al.
J Alzheimers Dis
. 2025 Mar;
:13872877251321116.
PMID: 40025729
To our knowledge, no reports have described nonhuman primate (NHP) models of frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) that do not depend on an overexpression paradigm. Based...
2.
Bay S, Rodina A, Haut F, Roychowdhury T, Argyrousi E, Staniszewski A, et al.
Res Sq
. 2025 Feb;
PMID: 39989971
Alzheimer's disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we provide a systems-level map...
3.
Watamura N, Foiani M, Bez S, Bourdenx M, Santambrogio A, Frodsham C, et al.
Nat Neurosci
. 2024 Dec;
28(2):293-307.
PMID: 39719507
Tau pathology is a hallmark of several neurodegenerative diseases, including frontotemporal dementia and Alzheimer's disease. However, the sequence of events and the form of tau that confers toxicity are still...
4.
Nagata K, Hashimoto S, Joho D, Fujioka R, Matsuba Y, Sekiguchi M, et al.
eNeuro
. 2024 Nov;
11(12).
PMID: 39592224
Unique microglial states have been identified in Alzheimer's disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial...
5.
Shimohama S, Fujioka R, Mihira N, Sekiguchi M, Sartori L, Joho D, et al.
J Neurosci
. 2024 Nov;
44(47).
PMID: 39496485
A previous epidemiological study in Northern Europe showed that the A673T mutation (Icelandic mutation) in the amyloid precursor protein gene () can protect against Alzheimer's disease (AD). While the effect...
6.
Iwata N, Tsubuki S, Sekiguchi M, Watanabe-Iwata K, Matsuba Y, Kamano N, et al.
Life Sci Alliance
. 2024 Sep;
7(12).
PMID: 39348937
The amyloid β peptide (Aβ), starting with pyroglutamate (pE) at position 3 and ending at position 42 (Aβ3pE-42), predominantly accumulates in the brains of Alzheimer's disease. Consistently, donanemab, a therapeutic...
7.
Wieg L, Ciola J, Wasen C, Gaba F, Colletti B, Schroeder M, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273325
Cosmic radiation experienced during space travel may increase the risk of cognitive impairment. While simulated galactic cosmic radiation (GCRsim) has led to memory deficits in wildtype (WT) mice, it has...
8.
Sato K, Sasaguri H, Kumita W, Sakuma T, Morioka T, Nagata K, et al.
Lab Anim (NY)
. 2024 Aug;
53(9):244-251.
PMID: 39215182
Nonhuman primates (NHPs), which are closely related to humans, are useful in biomedical research, and an increasing number of NHP disease models have been reported using gene editing. However, many...
9.
Daniels M, Lefevre L, Szymkowiak S, Drake A, McCulloch L, Tzioras M, et al.
Elife
. 2023 Dec;
12.
PMID: 38085657
Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both...
10.
Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, et al.
Sci Transl Med
. 2023 Sep;
15(713):eabo6889.
PMID: 37703352
Tau pathogenesis is a hallmark of many neurodegenerative diseases, including Alzheimer's disease (AD). Although the events leading to initial tau misfolding and subsequent tau spreading in patient brains are largely...