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Helen K Donnelly

Explore the profile of Helen K Donnelly including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 1773
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Recent Articles
1.
Grant R, Poor T, Sichizya L, Diaz E, Bailey J, Soni S, et al.
JCI Insight . 2024 Mar; 9(8). PMID: 38502186
BACKGROUNDSurvivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of...
2.
Rohani R, Yarnold P, Scheetz M, Neely M, Kang M, Donnelly H, et al.
Antimicrob Agents Chemother . 2023 Nov; 67(12):e0072723. PMID: 37975660
It is unclear whether plasma is a reliable surrogate for target attainment in the epithelial lining fluid (ELF). The objective of this study was to characterize meropenem target attainment in...
3.
Grant R, Poor T, Sichizya L, Diaz E, Bailey J, Soni S, et al.
bioRxiv . 2023 Aug; PMID: 37546860
Neurological impairment is the most common finding in patients with post-acute sequelae of COVID-19. Furthermore, survivors of pneumonia from any cause have an elevated risk of dementia. Dysfunction in microglia,...
4.
Pickens C, Gao C, Bodner J, Walter J, Kruser J, Donnelly H, et al.
Open Forum Infect Dis . 2023 Jul; 10(7):ofad336. PMID: 37520413
Background: Clinical end points that constitute successful treatment in severe pneumonia are difficult to ascertain and vulnerable to bias. The utility of a protocolized adjudication procedure to determine meaningful end...
5.
Gao C, Markov N, Stoeger T, Pawlowski A, Kang M, Nannapaneni P, et al.
J Clin Invest . 2023 Apr; 133(12). PMID: 37104035
BACKGROUNDDespite guidelines promoting the prevention and aggressive treatment of ventilator-associated pneumonia (VAP), the importance of VAP as a driver of outcomes in mechanically ventilated patients, including patients with severe COVID-19,...
6.
Rohani R, Scheetz M, Donnelly H, Donayre A, Kang M, Diaz E, et al.
J Antimicrob Chemother . 2022 Jul; 77(11):2956-2959. PMID: 35869779
Objectives: Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Methods: Meropenem plasma PK data (n = 70 patients) were modelled,...
7.
Grant R, Morales-Nebreda L, Markov N, Swaminathan S, Guzman E, Abbott D, et al.
bioRxiv . 2021 May; PMID: 34013276
One Sentence Summary: SARS-CoV-2-infected alveolar macrophages form positive feedback loops with T cells in patients with severe COVID-19.
8.
Pickens C, Qi C, Postelnick M, Paonessa J, Donnelly H, Wunderink R
Infect Control Hosp Epidemiol . 2021 Feb; 42(11):1385-1387. PMID: 33517926
Vancomycin overuse is common, yet few data are available regarding how to improve stewardship of this antibiotic. We identify an association between use of a PCR assay to rule out...
9.
Grant R, Morales-Nebreda L, Markov N, Swaminathan S, Querrey M, Guzman E, et al.
Nature . 2021 Jan; 590(7847):635-641. PMID: 33429418
Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop severe pneumonia and acute respiratory distress syndrome (ARDS). Distinct clinical features in these patients have led to speculation...
10.
Bergin S, Coles A, Calvert S, Farley J, Powers J, Zervos M, et al.
Chest . 2020 Jul; 158(6):2370-2380. PMID: 32615191
Background: Pneumonia is the leading infection-related cause of death. The use of simple clinical criteria and contemporary epidemiology to identify patients at high risk of nosocomial pneumonia should enhance prevention...