Navdeep S Chandel
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Explore the profile of Navdeep S Chandel including associated specialties, affiliations and a list of published articles.
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284
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30925
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Recent Articles
1.
Stewart A, Zachman D, Castellano-Escuder P, Kelly L, Zolyomi B, Aiduk M, et al.
bioRxiv
. 2025 Mar;
PMID: 40060603
Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights...
2.
Zhu P, Pfrender E, Steffeck A, Reczek C, Zhou Y, Thakkar A, et al.
Sci Adv
. 2025 Mar;
11(10):eadq8538.
PMID: 40043110
Circadian rhythms orchestrate physiological processes such as metabolism, immune function, and tissue regeneration, aligning them with the optimal time of day (TOD). This study identifies an interplay between the circadian...
3.
Reczek C, Chandel N
Annu Rev Cancer Biol
. 2025 Mar;
1:79-98.
PMID: 40034143
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling, facilitating cancer cell proliferation,...
4.
Runyan C, Luo L, Welch L, Lu Z, Chen F, Schleck M, et al.
bioRxiv
. 2025 Jan;
PMID: 39868236
Sarcopenia, which diminishes lifespan and healthspan in the elderly, is commonly exacerbated by viral pneumonia, including influenza and COVID-19. In a study of influenza A pneumonia in mice, young mice...
5.
Stoolman J, Grant R, Billingham L, Poor T, Weinberg S, Harding M, et al.
Sci Adv
. 2025 Jan;
11(4):eadu4369.
PMID: 39841842
Mitochondrial electron transport chain (ETC) function modulates macrophage biology; however, mechanisms underlying mitochondria ETC control of macrophage immune responses are not fully understood. Here, we report that mutant mice with...
6.
Yuan L, Chandel N, Julius D
bioRxiv
. 2025 Jan;
PMID: 39763883
The capsaicin receptor, TRPV1, mediates the detection of harmful chemical and thermal stimuli. Overactivation of TRPV1 can lead to cellular damage or death through excitotoxicity, a phenomenon associated with painful...
7.
Reczek C, Chakrabarty R, DAlessandro K, Sebo Z, Grant R, Gao P, et al.
Sci Adv
. 2024 Dec;
10(51):eads5466.
PMID: 39693440
Metformin is among the most prescribed antidiabetic drugs, but the primary molecular mechanism by which metformin lowers blood glucose levels is unknown. Previous studies have proposed numerous mechanisms by which...
8.
Karakousi T, Cristaldi V, Lopes de Oliveira M, Geraldo L, Gonzalez-Robles T, da Silva G, et al.
bioRxiv
. 2024 Dec;
PMID: 39677662
Lymphatic vessels play a crucial role in activating anti-tumor immune surveillance but also contribute to metastasis and systemic tumor progression. Whether distinct lymphatic phenotypes exist that govern the switch between...
9.
Tiwari R, Sharma R, Rajendran G, Borkowski G, An S, Schonfeld M, et al.
J Clin Invest
. 2024 Dec;
135(3).
PMID: 39621585
Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI...
10.
Liu X, Ren Z, Tan C, Nunez-Santana F, Kelly M, Yan Y, et al.
J Clin Invest
. 2024 Nov;
134(22).
PMID: 39545417
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for...