Benjamin D Singer
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Explore the profile of Benjamin D Singer including associated specialties, affiliations and a list of published articles.
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100
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4159
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Recent Articles
1.
Joudi A, Gurkan J, Liu Q, Acosta M, Helmin K, Morales-Nebreda L, et al.
bioRxiv
. 2025 Mar;
PMID: 40060513
FOXP3+ natural regulatory T cells (nTregs) promote resolution of inflammation and repair of epithelial damage following viral pneumonia-induced lung injury, thus representing a cellular therapy for patients with acute respiratory...
2.
Gao C, Markov N, Pickens C, Pawlowski A, Kang M, Walter J, et al.
Open Forum Infect Dis
. 2025 Mar;
12(3):ofaf090.
PMID: 40046892
Background: Critically ill patients who develop invasive pulmonary aspergillosis (IPA) have high mortality rates despite antifungal therapy. Diagnosis is difficult in these patients and incidences vary in the literature. Bronchoalveolar...
3.
Bodner J, Vadlamani P, Helmin K, Liu Q, Mendillo M, Singer B, et al.
bioRxiv
. 2025 Jan;
PMID: 39829857
Proper histone gene expression is critical to cell viability and maintaining genomic integrity. Multiple histone genes organized into three genomic loci encode for replication coupled core and linker histones. Histone...
4.
Reader B, Rosas L, Knopf B, Liu Y, Alzate-Correa D, Bhat A, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Dec;
80(2).
PMID: 39704343
As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of...
5.
Ma R, Prigge A, Ortiz Serrano T, Cheng Y, Davis J, Lou K, et al.
Cell Rep
. 2024 Dec;
43(12):115056.
PMID: 39645657
Forkhead box P3 (Foxp3) regulatory T cells (Tregs) resolve acute inflammation and repair the injured lung after viral pneumonia. Vimentin is a critical protein in the distal pole complex (DPC)...
6.
Zhu M, Pickens C, Markov N, Pawlowski A, Kang M, Rasmussen L, et al.
medRxiv
. 2024 Sep;
PMID: 39314979
Background: Antibiotic stewardship in critically ill pneumonia patients is crucial yet challenging, partly due to the limited diagnostic yield of noninvasive infectious tests. In this study, we report an antibiotic...
7.
Markov N, Ren Z, Senkow K, Grant R, Gao C, Malsin E, et al.
Nat Immunol
. 2024 Aug;
25(9):1607-1622.
PMID: 39138384
The evolution of T cell molecular signatures in the distal lung of patients with severe pneumonia is understudied. Here, we analyzed T cell subsets in longitudinal bronchoalveolar lavage fluid samples...
8.
Mambetsariev N, Acosta M, Liu Q, Flores C, Joudi A, Helmin K, et al.
bioRxiv
. 2024 Jun;
PMID: 38853959
FOXP3+ regulatory T (Treg) cells are necessary to coordinate resolution of lung inflammation and a return to homeostasis after respiratory viral infections, but the specific molecular requirements for these functions...
9.
Grudzinski K, Fenske S, Peltekian A, Markov N, Pawlowski A, Kang M, et al.
medRxiv
. 2024 May;
PMID: 38766045
Rationale: Pneumonia is the most common infection in ICU patients and a leading cause for death. Assessment of bronchoalveolar lavage fluid (BALF) cellularity can aid in pneumonia diagnosis. Low percentages...
10.
Waypa G, Smith K, Mungai P, Dudley V, Helmin K, Singer B, et al.
J Clin Invest
. 2024 May;
134(13).
PMID: 38722697
Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype that utilizes mitochondrial oxidative phosphorylation but loses mitotic capacity. We tested whether forced reversal of adult cardiomyocytes back...