Hassan Pajouhesh
Overview
Explore the profile of Hassan Pajouhesh including associated specialties, affiliations and a list of published articles.
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14
Citations
836
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Recent Articles
1.
Mulcahy J, Beckley J, Klas S, Odink D, Delwig A, Pajouhesh H, et al.
Br J Pharmacol
. 2024 May;
181(17):3160-3171.
PMID: 38715413
Background And Purpose: The voltage-gated sodium channel isoform Na1.7 is a high-interest target for the development of non-opioid analgesics due to its preferential expression in pain-sensing neurons. Na1.7 is also...
2.
Pajouhesh H, Delwig A, Beckley J, Klas S, Monteleone D, Zhou X, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1763-1768.
PMID: 36385936
The voltage-gated sodium channel isoform Na1.7 has drawn widespread interest as a target for non-opioid, investigational new drugs to treat pain. Selectivity over homologous, off-target sodium channel isoforms, which are...
3.
Beckley J, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, et al.
Pain
. 2020 Oct;
162(4):1250-1261.
PMID: 33086288
The voltage-gated sodium channel Nav1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Nav1.7 is a genetically validated pain target in humans because loss-of-function...
4.
Mulcahy J, Pajouhesh H, Beckley J, Delwig A, Du Bois J, Hunter J
J Med Chem
. 2019 Apr;
62(19):8695-8710.
PMID: 31012583
Voltage-gated sodium ion channel subtype 1.7 (Na1.7) is a high interest target for the discovery of non-opioid analgesics. Compelling evidence from human genetic data, particularly the finding that persons lacking...
5.
Johansen L, DeWald L, Shoemaker C, Hoffstrom B, Lear-Rooney C, Stossel A, et al.
Sci Transl Med
. 2015 Jun;
7(290):290ra89.
PMID: 26041706
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved...
6.
Borzenko A, Pajouhesh H, Morrison J, Tringham E, Snutch T, Schafer L
Bioorg Med Chem Lett
. 2013 May;
23(11):3257-61.
PMID: 23639535
A novel approach to the synthesis of substituted piperazines and their investigation as N-type calcium channel blockers is presented. A common scaffold exhibiting high activity as N-type blockers is N-substituted...
7.
Shoemaker C, Schornberg K, Delos S, Scully C, Pajouhesh H, Olinger G, et al.
PLoS One
. 2013 Feb;
8(2):e56265.
PMID: 23441171
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic...
8.
Pajouhesh H, Feng Z, Zhang L, Pajouhesh H, Jiang X, Hendricson A, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):4153-8.
PMID: 22579422
We previously reported the small organic N-type calcium channel blocker NP078585 that while efficacious in animal models for pain, exhibited modest L-type calcium channel selectivity and substantial off-target inhibition against...
9.
Tringham E, Powell K, Cain S, Kuplast K, Mezeyova J, Weerapura M, et al.
Sci Transl Med
. 2012 Feb;
4(121):121ra19.
PMID: 22344687
Absence seizures are a common seizure type in children with genetic generalized epilepsy and are characterized by a temporary loss of awareness, arrest of physical activity, and accompanying spike-and-wave discharges...
10.
Hildebrand M, Smith P, Bladen C, Eduljee C, Xie J, Chen L, et al.
Pain
. 2011 Feb;
152(4):833-843.
PMID: 21349638
Voltage-gated ion channels are implicated in pain sensation and transmission signaling mechanisms within both peripheral nociceptors and the spinal cord. Genetic knockdown and knockout experiments have shown that specific channel...