John V Mulcahy
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Explore the profile of John V Mulcahy including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
124
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Recent Articles
1.
Mulcahy J, Beckley J, Klas S, Odink D, Delwig A, Pajouhesh H, et al.
Br J Pharmacol
. 2024 May;
181(17):3160-3171.
PMID: 38715413
Background And Purpose: The voltage-gated sodium channel isoform Na1.7 is a high-interest target for the development of non-opioid analgesics due to its preferential expression in pain-sensing neurons. Na1.7 is also...
2.
Pajouhesh H, Delwig A, Beckley J, Klas S, Monteleone D, Zhou X, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1763-1768.
PMID: 36385936
The voltage-gated sodium channel isoform Na1.7 has drawn widespread interest as a target for non-opioid, investigational new drugs to treat pain. Selectivity over homologous, off-target sodium channel isoforms, which are...
3.
Beckley J, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, et al.
Pain
. 2020 Oct;
162(4):1250-1261.
PMID: 33086288
The voltage-gated sodium channel Nav1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Nav1.7 is a genetically validated pain target in humans because loss-of-function...
4.
Mulcahy J, Pajouhesh H, Beckley J, Delwig A, Du Bois J, Hunter J
J Med Chem
. 2019 Apr;
62(19):8695-8710.
PMID: 31012583
Voltage-gated sodium ion channel subtype 1.7 (Na1.7) is a high interest target for the discovery of non-opioid analgesics. Compelling evidence from human genetic data, particularly the finding that persons lacking...
5.
Mulcahy J, Walker J, Merit J, Whitehead A, Du Bois J
J Am Chem Soc
. 2016 May;
138(18):5994-6001.
PMID: 27138488
The paralytic shellfish poisons are a collection of guanidine-containing natural products that are biosynthesized by prokaryote and eukaryote marine organisms. These compounds bind and inhibit isoforms of the mammalian voltage-gated...
6.
Eberlin L, Mulcahy J, Tzabazis A, Zhang J, Liu H, Logan M, et al.
J Am Chem Soc
. 2014 Apr;
136(17):6401-5.
PMID: 24708172
Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass...
7.
Mulcahy J, Du Bois J
J Am Chem Soc
. 2008 Sep;
130(38):12630-1.
PMID: 18759394
An asymmetric synthesis of the paralytic shellfish poison (PSP), (+)-gonyautoxin 3, is described. A unique, Rh-catalyzed amination reaction provides rapid access to the heteratom-rich, tricyclic core of the toxin, which...
8.
Kim M, Mulcahy J, Espino C, Du Bois J
Org Lett
. 2006 Mar;
8(6):1073-6.
PMID: 16524271
[reaction: see text] Oxidative C-H amination of N-trichloroethoxysulfonyl-protected ureas and guanidines is demonstrated to proceed in high yield for tertiary and benzylic-derived substrates. The success of these reactions is predicated...