Hassan Pajouhesh
Overview
Explore the profile of Hassan Pajouhesh including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
836
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0
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Recent Articles
11.
Pajouhesh H, Feng Z, Ding Y, Zhang L, Pajouhesh H, Morrison J, et al.
Bioorg Med Chem Lett
. 2010 Feb;
20(4):1378-83.
PMID: 20117000
A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC(50) values in the range...
12.
Zamponi G, Feng Z, Zhang L, Pajouhesh H, Ding Y, Belardetti F, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(22):6467-72.
PMID: 19815411
The therapeutic agents flunarizine and lomerizine exhibit inhibitory activities against a variety of ion channels and neurotransmitter receptors. We have optimized their scaffolds to obtain more selective N-type calcium channel...
13.
Belardetti F, Tringham E, Eduljee C, Jiang X, Dong H, Hendricson A, et al.
Assay Drug Dev Technol
. 2009 Jun;
7(3):266-80.
PMID: 19530894
T-type voltage-gated Ca(2+) channels have been implicated in contributing to a broad variety of human disorders, including pain, epilepsy, sleep disturbances, cardiac arrhythmias, and certain types of cancer. However, potent...
14.
Pajouhesh H, Lenz G
NeuroRx
. 2006 Feb;
2(4):541-53.
PMID: 16489364
Fundamental physiochemical features of CNS drugs are related to their ability to penetrate the blood-brain barrier affinity and exhibit CNS activity. Factors relevant to the success of CNS drugs are...