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» Authors » Harshitha Pidikiti

Harshitha Pidikiti

Explore the profile of Harshitha Pidikiti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 9
Followers 0
Related Specialties
Neurology
Biology
Physiology
Top 10 Co-Authors
Melissa J Alldred
Stephen D Ginsberg
Adriana Heguy
Elliott J Mufson
Grace E Stutzmann
Kyrillos W Ibrahim
Sang Han Lee
Gabriela Chiosis
Gabriel E Hoffman
Panos Roussos
Published In
FASEB J
Acta Neuropathol
Traffic
Acta Neuropathol Commun
J Alzheimers Dis
Affiliations
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Recent Articles
1.
Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease
Alldred M, Ibrahim K, Pidikiti H, Lee S, Heguy A, Chiosis G, et al.
Front Mol Neurosci . 2025 Mar; 18:1546375. PMID: 40078964
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal...
2.
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals
Alldred M, Ibrahim K, Pidikiti H, Chiosis G, Mufson E, Stutzmann G, et al.
Acta Neuropathol Commun . 2024 Nov; 12(1):182. PMID: 39605035
Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer's disease (AD), resulting in disproportional degeneration of pyramidal neurons (PNs) affecting memory and executive function. Elucidating the...
3.
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
Acta Neuropathol . 2024 Aug; 148(1):16. PMID: 39105932
We elucidated the molecular fingerprint of vulnerable excitatory neurons within select cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and therapeutic potential that also informs Alzheimer's disease...
4.
Hippocampal CA1 Pyramidal Neurons Display Sublayer and Circuitry Dependent Degenerative Expression Profiles in Aged Female Down Syndrome Mice
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
J Alzheimers Dis . 2024 Jul; 100(s1):S341-S362. PMID: 39031371
Background: Individuals with Down syndrome (DS) have intellectual disability and develop Alzheimer's disease (AD) pathology during midlife, particularly in the hippocampal component of the medial temporal lobe memory circuit. However,...
5.
Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging
Peng K, Liemisa B, Pasato J, DAcunzo P, Pawlik M, Heguy A, et al.
Traffic . 2024 May; 25(5):e12937. PMID: 38777335
The polymorphic APOE gene is the greatest genetic determinant of sporadic Alzheimer's disease risk: the APOE4 allele increases risk, while the APOE2 allele is neuroprotective compared with the risk-neutral APOE3...
6.
Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation
Alldred M, Pidikiti H, Heguy A, Roussos P, Ginsberg S
FASEB J . 2023 May; 37(6):e22944. PMID: 37191946
Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD). Current therapeutics in these disorders have been unsuccessful in slowing disease progression, likely...