Elliott J Mufson
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Explore the profile of Elliott J Mufson including associated specialties, affiliations and a list of published articles.
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190
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8986
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Recent Articles
1.
Alldred M, Ibrahim K, Pidikiti H, Lee S, Heguy A, Chiosis G, et al.
Front Mol Neurosci
. 2025 Mar;
18:1546375.
PMID: 40078964
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal...
2.
Counts S, Beck J, Maloney B, Malek-Ahmadi M, Ginsberg S, Mufson E, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e70019.
PMID: 40008917
Introduction: MicroRNA (miRNA) activity is increasingly appreciated as a key regulator of pathophysiologic pathways in Alzheimer's disease (AD). However, the role of miRNAs during the progression of AD, including resilience...
3.
Moreno-Rodriguez M, Perez S, Malek-Ahmadi M, Mufson E
J Neuroinflammation
. 2025 Jan;
22(1):25.
PMID: 39885546
The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. However, its effects on the lipid...
4.
Tallino S, Etebari R, McDonough I, Leon H, Sepulveda I, Winslow W, et al.
Nutrients
. 2024 Dec;
16(23).
PMID: 39683562
Background/objectives: Down syndrome (DS) is the most common cause of early-onset Alzheimer's disease (AD). Dietary choline has been proposed as a modifiable factor to improve the cognitive and pathological outcomes...
5.
Alldred M, Ibrahim K, Pidikiti H, Chiosis G, Mufson E, Stutzmann G, et al.
Acta Neuropathol Commun
. 2024 Nov;
12(1):182.
PMID: 39605035
Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer's disease (AD), resulting in disproportional degeneration of pyramidal neurons (PNs) affecting memory and executive function. Elucidating the...
6.
Gautier M, Kelley C, Lee S, Mufson E, Ginsberg S
Neurobiol Aging
. 2024 Sep;
144:30-42.
PMID: 39265450
Individuals with DS develop Alzheimer's disease (AD) neuropathology, including endosomal-lysosomal system abnormalities and degeneration of basal forebrain cholinergic neurons (BFCNs). We investigated whether maternal choline supplementation (MCS) affects early endosome...
7.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
Acta Neuropathol
. 2024 Aug;
148(1):16.
PMID: 39105932
We elucidated the molecular fingerprint of vulnerable excitatory neurons within select cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and therapeutic potential that also informs Alzheimer's disease...
8.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
J Alzheimers Dis
. 2024 Jul;
100(s1):S341-S362.
PMID: 39031371
Background: Individuals with Down syndrome (DS) have intellectual disability and develop Alzheimer's disease (AD) pathology during midlife, particularly in the hippocampal component of the medial temporal lobe memory circuit. However,...
9.
Granholm A, Englund E, Gilmore A, Head E, Yong W, Perez S, et al.
Acta Neuropathol
. 2024 May;
147(1):92.
PMID: 38801558
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality risk for people with Alzheimer's disease (AD) and/or...
10.
Ortiz C, Pearson A, McCartan R, Roche S, Carothers N, Browning M, et al.
J Neuroinflammation
. 2024 May;
21(1):130.
PMID: 38750510
Epidemiological studies have unveiled a robust link between exposure to repetitive mild traumatic brain injury (r-mTBI) and elevated susceptibility to develop neurodegenerative disorders, notably chronic traumatic encephalopathy (CTE). The pathogenic...