Gabriel E Hoffman
Overview
Explore the profile of Gabriel E Hoffman including associated specialties, affiliations and a list of published articles.
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73
Citations
2798
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Recent Articles
1.
Hoffman G, Hoffman G, Roussos P
Res Sq
. 2025 Mar;
PMID: 40060050
Changes in cell type composition play an important role in human health and disease. Recent advances in single-cell technology have enabled the measurement of cell type composition at increasing cell...
2.
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, et al.
Nat Genet
. 2025 Mar;
57(3):604-615.
PMID: 40033057
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. Mapping the genetics of gene expression in human microglia has identified several...
3.
Hoffman G, Roussos P
bioRxiv
. 2025 Feb;
PMID: 39975411
Changes in cell type composition play an important role in human health and disease. Recent advances in single-cell technology have enabled the measurement of cell type composition at increasing cell...
4.
Clarence T, Bendl J, Cao X, Wang X, Zheng S, Hoffman G, et al.
Nat Genet
. 2025 Feb;
57(3):591-603.
PMID: 39962241
Human brain development spans from embryogenesis to adulthood, with dynamic gene expression controlled by cell-type-specific cis-regulatory element activity and three-dimensional genome organization. To advance our understanding of postnatal brain development,...
5.
Voloudakis G, Lee K, Vicari J, Zhang W, Hoagland D, Venkatesh S, et al.
medRxiv
. 2025 Jan;
PMID: 39867394
Background: The development and approval of novel drugs are typically time-intensive and expensive. Leveraging a computational drug repurposing framework that integrates disease-relevant genetically regulated gene expression (GReX) and large longitudinal...
6.
Bendl J, Fullard J, Girdhar K, Dong P, Kosoy R, Zeng B, et al.
Trends Genet
. 2025 Jan;
PMID: 39855972
Neuropsychiatric and neurodegenerative diseases have a significant genetic component. Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) and chromatin structure, ultimately impacting gene expression. Chromatin accessibility profiling...
7.
Zeng B, Yang H, N M P, Venkatesh S, Mathur D, Auluck P, et al.
Res Sq
. 2024 Dec;
PMID: 39711543
Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics,...
8.
Lee D, Vicari J, Porras C, Spencer C, Pjanic M, Wang X, et al.
medRxiv
. 2024 Dec;
PMID: 39677435
The complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer's disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human...
9.
Voloudakis G, Therrien K, Tomasi S, Rajagopal V, Choi S, Demontis D, et al.
Nat Hum Behav
. 2024 Dec;
PMID: 39658624
Polygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection of complex traits. Here, in 421,889 individuals with European ancestry from the Million Veteran Program and UK Biobank,...
10.
Dong P, Song L, Bendl J, Misir R, Shao Z, Edelstien J, et al.
Nat Commun
. 2024 Nov;
15(1):10113.
PMID: 39578476
Brain region- and cell-specific transcriptomic and epigenomic features are associated with heritability for neuropsychiatric traits, but a systematic view, considering cortical and subcortical regions, is lacking. Here, we provide an...