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Grace E Stutzmann

Explore the profile of Grace E Stutzmann including associated specialties, affiliations and a list of published articles. Areas
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Articles 48
Citations 1991
Followers 0
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Recent Articles
1.
Alldred M, Ibrahim K, Pidikiti H, Lee S, Heguy A, Chiosis G, et al.
Front Mol Neurosci . 2025 Mar; 18:1546375. PMID: 40078964
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal...
2.
Alldred M, Ibrahim K, Pidikiti H, Chiosis G, Mufson E, Stutzmann G, et al.
Acta Neuropathol Commun . 2024 Nov; 12(1):182. PMID: 39605035
Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer's disease (AD), resulting in disproportional degeneration of pyramidal neurons (PNs) affecting memory and executive function. Elucidating the...
3.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
Acta Neuropathol . 2024 Aug; 148(1):16. PMID: 39105932
We elucidated the molecular fingerprint of vulnerable excitatory neurons within select cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and therapeutic potential that also informs Alzheimer's disease...
4.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
J Alzheimers Dis . 2024 Jul; 100(s1):S341-S362. PMID: 39031371
Background: Individuals with Down syndrome (DS) have intellectual disability and develop Alzheimer's disease (AD) pathology during midlife, particularly in the hippocampal component of the medial temporal lobe memory circuit. However,...
5.
Taha M, Assali E, Ben-Kasus Nissim T, Stutzmann G, Shirihai O, Hershfinkel M, et al.
Mol Metab . 2024 Jul; 87:101982. PMID: 38960129
Objective: Hepatic Ca signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca signaling and their contribution to metabolic activity remain,...
6.
Stutzmann G, Soboloff J
J Physiol . 2024 Apr; 602(8):1445-1447. PMID: 38578234
No abstract available.
7.
Gautier M, Kelley C, Lee S, Alldred M, McDaid J, Mufson E, et al.
Neurobiol Dis . 2023 Oct; 188:106332. PMID: 37890559
Down syndrome (DS) is a genetic disorder caused by triplication of human chromosome 21. In addition to intellectual disability, DS is defined by a premature aging phenotype and Alzheimer's disease...
8.
Bazarek S, Thaqi M, King P, Mehta A, Patel R, Briggs C, et al.
Front Neurosci . 2023 Sep; 17:1237176. PMID: 37662111
Adult tissue stem cells contribute to tissue homeostasis and repair but the long-lived neurons in the human adult cerebral cortex are not replaced, despite evidence for a limited regenerative response....
9.
Webber E, Fivaz M, Stutzmann G, Griffioen G
Alzheimers Dement . 2023 May; 19(8):3701-3717. PMID: 37132525
This review discusses the driving principles that may underlie neurodegeneration in dementia, represented most dominantly by Alzheimer's disease (AD). While a myriad of different disease risk factors contribute to AD,...
10.
Wiseman A, Briggs C, Peritt A, Kapecki N, Peterson D, Shim S, et al.
J Alzheimers Dis . 2022 Nov; 91(1):273-290. PMID: 36442195
Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder with a progressive loss of cognitive function. Currently, no effective treatment regimen is available. Lithium, a mood stabilizer for bipolar disorder,...