Hanspeter Herzel
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Explore the profile of Hanspeter Herzel including associated specialties, affiliations and a list of published articles.
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141
Citations
3992
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Recent Articles
1.
Ector C, Didier J, De Landtsheer S, Nordentoft M, Schmal C, Keilholz U, et al.
Mol Syst Biol
. 2025 Feb;
PMID: 39994450
The circadian clock regulates key physiological processes, including cellular responses to DNA damage. Circadian-based therapeutic strategies optimize treatment timing to enhance drug efficacy and minimize side effects, offering potential for...
2.
Ector C, Schmal C, Didier J, De Landtsheer S, Finger A, Muller-Marquardt F, et al.
Nat Commun
. 2024 Aug;
15(1):7205.
PMID: 39169017
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the...
3.
Gabriel C, Del Olmo M, Rizki Widini A, Roshanbin R, Woyde J, Hamza E, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(34):e2404738121.
PMID: 39141353
Most mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known...
4.
Grabe S, Ananthasubramaniam B, Herzel H
Sci Rep
. 2024 Jul;
14(1):16238.
PMID: 39004631
Healthy mammalian cells have a circadian clock, a gene regulatory network that allows them to schedule their physiological processes to optimal times of the day. When healthy cells turn into...
5.
Del Olmo M, Legewie S, Brunner M, Hofer T, Kramer A, Bluthgen N, et al.
J Biol Chem
. 2024 Mar;
300(5):107220.
PMID: 38522517
Circadian rhythms are generated by complex interactions among genes and proteins. Self-sustained ∼24 h oscillations require negative feedback loops and sufficiently strong nonlinearities that are the product of molecular and...
6.
Del Olmo M, Kalashnikov A, Schmal C, Kramer A, Herzel H
Heliyon
. 2024 Feb;
10(2):e24773.
PMID: 38312577
Circadian clocks are endogenous oscillators present in almost all cells that drive daily rhythms in physiology and behavior. There are two mechanisms that have been proposed to explain how circadian...
7.
Gutu N, Binish N, Keilholz U, Herzel H, Granada A
Commun Biol
. 2023 Nov;
6(1):1196.
PMID: 38001355
Cells must accurately and quickly detect DNA damage through a set of checkpoint mechanisms that enable repair and control proliferation. Heterogeneous levels of cellular stress and noisy signaling processes can...
8.
Del Olmo M, Schmal C, Mizaikoff C, Grabe S, Gabriel C, Kramer A, et al.
F1000Res
. 2023 Sep;
12:1077.
PMID: 37771612
Three parameters are important to characterize a circadian and in general any biological clock: period, phase and amplitude. While circadian periods have been shown to correlate with entrainment phases, and...
9.
Schmal C, Maier B, Ashwal-Fluss R, Bartok O, Finger A, Bange T, et al.
PLoS Biol
. 2023 Jun;
21(6):e3002164.
PMID: 37379316
A defining property of circadian clocks is temperature compensation, characterized by the resilience of their near 24-hour free-running periods against changes in environmental temperature within the physiological range. While temperature...
10.
Grabe S, Mahammadov E, Del Olmo M, Herzel H
Front Netw Physiol
. 2023 Mar;
1:803011.
PMID: 36925578
Circadian rhythms are biological rhythms with a period close to 24 h. They become entrained to the Earth's solar day different periodic cues, so-called zeitgebers. The entrainment of circadian rhythms...