Hanspeter Herzel
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Explore the profile of Hanspeter Herzel including associated specialties, affiliations and a list of published articles.
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141
Citations
3992
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Recent Articles
11.
Del Olmo M, Sporl F, Korge S, Jurchott K, Felten M, Grudziecki A, et al.
NAR Genom Bioinform
. 2023 Jan;
4(4):lqac097.
PMID: 36601580
The skin is the largest human organ with a circadian clock that regulates its function. Although circadian rhythms in specific functions are known, rhythms in the proximal clock output, gene...
12.
Ivanov A, Mattei D, Radscheit K, Compagnion A, Pett J, Herzel H, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293208
Circular RNAs (circRNAs) are a large class of relatively stable RNA molecules that are highly expressed in animal brains. Many circRNAs have been associated with CNS disorders accompanied by an...
13.
Del Olmo M, Grabe S, Herzel H
Methods Mol Biol
. 2022 May;
2482:55-80.
PMID: 35610419
Circadian clocks are autonomous systems able to oscillate in a self-sustained manner in the absence of external cues, although such Zeitgebers are typically present. At the cellular level, the molecular...
14.
Fischer M, Herzel H, Bluthgen N
Sci Rep
. 2022 Apr;
12(1):5569.
PMID: 35368028
The intestinal epithelium is one of the fastest renewing tissues in mammals. It shows a hierarchical organisation, where intestinal stem cells at the base of crypts give rise to rapidly...
15.
Burt P, Grabe S, Madeti C, Upadhyay A, Merrow M, Roenneberg T, et al.
iScience
. 2021 Nov;
24(11):103370.
PMID: 34816105
Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail...
16.
Finger A, Jaschke S, Del Olmo M, Hurwitz R, Granada A, Herzel H, et al.
Sci Adv
. 2021 Jul;
7(30).
PMID: 34301601
Coupling between cell-autonomous circadian oscillators is crucial to prevent desynchronization of cellular networks and disruption of circadian tissue functions. While neuronal oscillators within the mammalian central clock, the suprachiasmatic nucleus,...
17.
Pelikan A, Herzel H, Kramer A, Ananthasubramaniam B
FEBS J
. 2021 Jun;
289(21):6605-6621.
PMID: 34189845
The circadian clock modulates key physiological processes in many organisms. This widespread role of circadian rhythms is typically characterized at the molecular level by profiling the transcriptome at multiple time...
18.
Gabriel C, Del Olmo M, Zehtabian A, Jager M, Reischl S, van Dijk H, et al.
Nat Commun
. 2021 Jun;
12(1):3796.
PMID: 34145278
The cell biology of circadian clocks is still in its infancy. Here, we describe an efficient strategy for generating knock-in reporter cell lines using CRISPR technology that is particularly useful...
19.
Lachmann G, Ananthasubramaniam B, Wunsch V, Scherfig L, Von Haefen C, Knaak C, et al.
Ann Intensive Care
. 2021 Apr;
11(1):64.
PMID: 33900485
Background: Despite the intensive efforts to improve the diagnosis and therapy of sepsis over the last decade, the mortality of septic shock remains high and causes substantial socioeconomical burden of...
20.
Upadhyay A, Marzoll D, Diernfellner A, Brunner M, Herzel H
Sci Rep
. 2020 Dec;
10(1):22224.
PMID: 33335302
Theory predicts that self-sustained oscillations require robust delays and nonlinearities (ultrasensitivity). Delayed negative feedback loops with switch-like inhibition of transcription constitute the core of eukaryotic circadian clocks. The kinetics of...