Karl Deisseroth
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Explore the profile of Karl Deisseroth including associated specialties, affiliations and a list of published articles.
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Articles
417
Citations
57586
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Recent Articles
1.
Attarpour A, Osmann J, Rinaldi A, Qi T, Lal N, Patel S, et al.
Nat Methods
. 2025 Jan;
22(3):600-611.
PMID: 39870865
Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that...
2.
Duncan L, Li T, Salem M, Li W, Mortazavi L, Senturk H, et al.
Nat Neurosci
. 2025 Jan;
28(2):248-258.
PMID: 39833308
Psychiatric disorders are multifactorial and effective treatments are lacking. Probable contributing factors to the challenges in therapeutic development include the complexity of the human brain and the high polygenicity of...
3.
Kimmey B, Ejoh L, Shangloo L, Wojick J, Chehimi S, McCall N, et al.
bioRxiv
. 2025 Jan;
PMID: 39803541
Pain is a dynamic and nonlinear experience shaped by injury and contextual factors, including expectations of future pain or relief. While μ opioid receptors are central to the analgesic effects...
4.
Chapman P, Kulkarni A, Trevisan A, Han K, Hinton J, Deltuvaite P, et al.
Neuron
. 2024 Dec;
113(4):524-538.e6.
PMID: 39719703
Motor output results from the coordinated activity of neural circuits distributed across multiple brain regions that convey information to the spinal cord via descending motor pathways. Yet the organizational logic...
5.
Drexler R, Drinnenberg A, Gavish A, Yalcin B, Shamardani K, Rogers A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386427
Neuronal activity promotes the proliferation of healthy oligodendrocyte precursor cells (OPC) and their malignant counterparts, gliomas. Many gliomas arise from and closely resemble oligodendroglial lineage precursors, including diffuse midline glioma...
6.
Prevost E, Phillips A, Lauridsen K, Enserro G, Rubinstein B, Alas D, et al.
J Neurosci
. 2024 Sep;
44(46).
PMID: 39327007
A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities....
7.
Kelley K, Revah O, Gore F, Kaganovsky K, Chen X, Deisseroth K, et al.
Nat Protoc
. 2024 Jul;
19(12):3542-3567.
PMID: 39075308
Human neural organoids represent promising models for studying neural function; however, organoids grown in vitro lack certain microenvironments and sensory inputs that are thought to be essential for maturation. The...
8.
Dunning J, Lopez C, Krull C, Kreifeldt M, Angelo M, Shu L, et al.
Mol Psychiatry
. 2024 Jul;
30(1):37-49.
PMID: 38965421
The parasubthalamic nucleus (PSTN) is activated by refeeding after food deprivation and several PSTN subpopulations have been shown to suppress feeding. However, no study to date directly addressed the role...
9.
Ratliff J, Terral G, Lutzu S, Heiss J, Mota J, Stith B, et al.
bioRxiv
. 2024 Jul;
PMID: 38948753
Behavioral states such as sleep and wake are highly correlated with specific patterns of rhythmic activity in the cortex. During low arousal states such as slow wave sleep, the cortex...
10.
McGovern D, Phillips A, Ly A, Prevost E, Ward L, Siletti K, et al.
bioRxiv
. 2024 Jun;
PMID: 38915564
Ventral tegmental area (VTA) glutamatergic neurons participate in reward, aversion, drug-seeking, and stress. Subsets of VTA VGluT2+ neurons are capable of co-transmitting glutamate and GABA (VGluT2+VGaT+ neurons), transmitting glutamate without...