Gunther Bernhardt
Overview
Explore the profile of Gunther Bernhardt including associated specialties, affiliations and a list of published articles.
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Articles
103
Citations
941
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Recent Articles
1.
Gratz L, Muller C, Pegoli A, Schindler L, Bernhardt G, Littmann T
ACS Pharmacol Transl Sci
. 2022 Nov;
5(11):1142-1155.
PMID: 36407949
Luminescence-based techniques play an increasingly important role in all areas of biochemical research, including investigations on G protein-coupled receptors (GPCRs). One quite recent and popular addition has been made by...
2.
Schindler L, Moosbauer J, Schmidt D, Spruss T, Gratz L, Ludeke S, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230845
Overexpression of the neurotensin receptor type 1 (NTSR), a peptide receptor located at the plasma membrane, has been reported for a variety of malignant tumors. Thus, targeting the NTSR with...
3.
Gratz L, Tropmann K, Bresinsky M, Muller C, Bernhardt G, Pockes S
Sci Rep
. 2021 Jun;
11(1):12444.
PMID: 34103640
No abstract available.
4.
Littmann T, Ozawa T, Bernhardt G
Methods Mol Biol
. 2021 May;
2274:69-78.
PMID: 34050463
G Protein-coupled receptors (GPCRs) transduce signals elicited by bioactive chemical agents (ligands), such as hormones, neurotransmitters, or cytokines, across the cellular membrane. Upon ligand binding, the receptor undergoes structural rearrangements,...
5.
Gratz L, Tropmann K, Bresinsky M, Muller C, Bernhardt G, Pockes S
Sci Rep
. 2021 May;
11(1):10747.
PMID: 34006951
No abstract available.
6.
Biselli S, Bresinsky M, Tropmann K, Forster L, Honisch C, Buschauer A, et al.
Eur J Med Chem
. 2021 Feb;
214:113190.
PMID: 33548637
Even today, the role of the histamine H receptor (HR) in the central nervous system (CNS) is widely unknown. In previous research, many dimeric, high-affinity and subtype-selective carbamoylguanidine-type ligands such...
7.
Buschmann J, Seiler T, Bernhardt G, Keller M, Wifling D
RSC Med Chem
. 2021 Jan;
11(2):274-282.
PMID: 33479634
The recently resolved crystal structure of the neuropeptide Y Y receptor (YR), co-crystallized with the high-affinity (p : 10.11), argininamide-type YR antagonist UR-MK299 (), revealed that the -carbamoyl substituent (van...
8.
Antoni F, Bernhardt G
Arch Pharm (Weinheim)
. 2020 Dec;
354(4):e2000366.
PMID: 33283341
In previous studies, we demonstrated that esters of bendamustine containing a basic moiety are far more cytotoxic anticancer agents than their parent compound and that the substitution of the labile...
9.
Antoni F, Wifling D, Bernhardt G
Eur J Med Chem
. 2020 Nov;
210:112958.
PMID: 33199153
A good balance between hydrophilicity and lipophilicity is a prerequisite for all bioactive compounds. If the hydrophilicity of a compound is low, its solubility in water will be meager. Many...
10.
Horing C, Seibel U, Tropmann K, Gratz L, Monnich D, Pitzl S, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33182741
In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of...