David Wifling
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Explore the profile of David Wifling including associated specialties, affiliations and a list of published articles.
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18
Citations
174
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Recent Articles
1.
Bhati A, Wan S, Alfe D, Clyde A, Bode M, Tan L, et al.
Interface Focus
. 2021 Dec;
11(6):20210018.
PMID: 34956592
The race to meet the challenges of the global pandemic has served as a reminder that the existing drug discovery process is expensive, inefficient and slow. There is a major...
2.
Konieczny A, Conrad M, Ertl F, Gleixner J, Gattor A, Gratz L, et al.
J Med Chem
. 2021 Nov;
64(22):16746-16769.
PMID: 34748345
The family of neuropeptide Y (NPY) receptors comprises four subtypes (YR, YR, YR, YR), which are addressed by at least three endogenous peptides, i.e., NPY, peptide YY, and pancreatic polypeptide...
3.
Weinhart C, Wifling D, Schmidt M, Neu E, Horing C, Clark T, et al.
Eur J Med Chem
. 2021 Feb;
213:113159.
PMID: 33571911
The family of human muscarinic acetylcholine receptors (MRs) is characterized by a high sequence homology among the five subtypes (MR-MR), being the reason for a lack of subtype selective MR...
4.
Buschmann J, Seiler T, Bernhardt G, Keller M, Wifling D
RSC Med Chem
. 2021 Jan;
11(2):274-282.
PMID: 33479634
The recently resolved crystal structure of the neuropeptide Y Y receptor (YR), co-crystallized with the high-affinity (p : 10.11), argininamide-type YR antagonist UR-MK299 (), revealed that the -carbamoyl substituent (van...
5.
Antoni F, Wifling D, Bernhardt G
Eur J Med Chem
. 2020 Nov;
210:112958.
PMID: 33199153
A good balance between hydrophilicity and lipophilicity is a prerequisite for all bioactive compounds. If the hydrophilicity of a compound is low, its solubility in water will be meager. Many...
6.
Konieczny A, Braun D, Wifling D, Bernhardt G, Keller M
J Med Chem
. 2020 Jul;
63(15):8198-8215.
PMID: 32614182
Within the family of neuropeptide Y (NPY) receptors, the Y receptor (YR) is unique as it prefers pancreatic polypeptide over NPY and peptide YY. Today, low-molecular-weight YR ligands are lacking,...
7.
Bartole E, Gratz L, Littmann T, Wifling D, Seibel U, Buschauer A, et al.
J Med Chem
. 2020 May;
63(10):5297-5311.
PMID: 32420741
Comprehensively characterized fluorescent probes for the histamine H receptor (HR) and especially for the HR orthologs [e.g., human (h) and mouse (m)] are highly needed as versatile complementary tools to...
8.
She X, Pegoli A, Gruber C, Wifling D, Carpenter J, Hubner H, et al.
J Med Chem
. 2020 Apr;
63(8):4133-4154.
PMID: 32233403
Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high MR affinities (p (radioligand...
9.
Wifling D, Pfleger C, Kaindl J, Ibrahim P, Kling R, Buschauer A, et al.
Chemistry
. 2019 Sep;
25(64):14613-14624.
PMID: 31498478
Histamine H receptor (H R) orthologues are G-protein-coupled receptors (GPCRs) that exhibit species-dependent basal activity. In contrast to the basally inactive mouse H R (mH R), human H R (hH...
10.
Ibrahim P, Wifling D, Clark T
J Chem Inf Model
. 2019 Aug;
59(9):3938-3945.
PMID: 31448910
An index of the activation of Class A G-protein-coupled receptors (GPCRs) has been trained using interhelix distances from a series of microsecond molecular-dynamics simulations and tested for 268 published X-ray...