Gunther Bernhardt
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Explore the profile of Gunther Bernhardt including associated specialties, affiliations and a list of published articles.
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103
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941
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Recent Articles
11.
Forster L, Gratz L, Monnich D, Bernhardt G, Pockes S
Int J Mol Sci
. 2020 Aug;
21(17).
PMID: 32847148
Investigations on functional selectivity of GPCR ligands have become increasingly important to identify compounds with a potentially more beneficial side effect profile. In order to discriminate between individual signaling pathways,...
12.
Biselli S, Alencastre I, Tropmann K, Erdmann D, Chen M, Littmann T, et al.
ACS Med Chem Lett
. 2020 Aug;
11(8):1521-1528.
PMID: 32832018
Fluorescence labeled ligands have been gaining importance as molecular tools, enabling receptor-ligand-binding studies by various fluorescence-based techniques. Aiming at red-emitting fluorescent ligands for the hHR, a series of squaramides labeled...
13.
Gratz L, Tropmann K, Bresinsky M, Muller C, Bernhardt G, Pockes S
Sci Rep
. 2020 Aug;
10(1):13288.
PMID: 32764682
Fluorescence/luminescence-based techniques play an increasingly important role in the development of test systems for the characterization of future drug candidates, especially in terms of receptor binding in the field of...
14.
Konieczny A, Braun D, Wifling D, Bernhardt G, Keller M
J Med Chem
. 2020 Jul;
63(15):8198-8215.
PMID: 32614182
Within the family of neuropeptide Y (NPY) receptors, the Y receptor (YR) is unique as it prefers pancreatic polypeptide over NPY and peptide YY. Today, low-molecular-weight YR ligands are lacking,...
15.
Bartole E, Gratz L, Littmann T, Wifling D, Seibel U, Buschauer A, et al.
J Med Chem
. 2020 May;
63(10):5297-5311.
PMID: 32420741
Comprehensively characterized fluorescent probes for the histamine H receptor (HR) and especially for the HR orthologs [e.g., human (h) and mouse (m)] are highly needed as versatile complementary tools to...
16.
She X, Pegoli A, Gruber C, Wifling D, Carpenter J, Hubner H, et al.
J Med Chem
. 2020 Apr;
63(8):4133-4154.
PMID: 32233403
Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high MR affinities (p (radioligand...
17.
Spinnler K, von Kruchten L, Konieczny A, Schindler L, Bernhardt G, Keller M
ACS Med Chem Lett
. 2020 Mar;
11(3):334-339.
PMID: 32184966
Lately, amino-functionalized -carbamoylated arginines were introduced as arginine surrogates enabling peptide labeling. However, this approach is hardly compatible with peptides also containing lysine or cysteine. Here, we present the synthesis...
18.
Antoni F, Bause M, Scholler M, Bauer S, Stark S, Jackson S, et al.
Eur J Med Chem
. 2020 Feb;
191:112133.
PMID: 32105979
Tariquidar derivatives have been described as potent and selective ABCG2 inhibitors. However, their susceptibility to hydrolysis limits their applicability. The current study comprises the synthesis and characterization of novel tariquidar-related...
19.
Keller M, Mahuroof S, Hong Yee V, Carpenter J, Schindler L, Littmann T, et al.
ACS Med Chem Lett
. 2020 Jan;
11(1):16-22.
PMID: 31938457
Fluorescence-labeled receptor ligands have emerged as valuable molecular tools, being indispensable for studying receptor-ligand interactions by fluorescence-based techniques such as high-content imaging, fluorescence microscopy, and fluorescence polarization. Through application of...
20.
Maschauer S, Ott J, Bernhardt G, Kuwert T, Keller M, Prante O
Sci Rep
. 2019 Sep;
9(1):12990.
PMID: 31506520
Neuropeptide Y Y receptors (YR) have been found to be overexpressed in a number of different tumours, such as breast, ovarian or renal cell cancer. In mammary carcinoma the high...