Gregory M Dillon
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Explore the profile of Gregory M Dillon including associated specialties, affiliations and a list of published articles.
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12
Citations
171
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Recent Articles
1.
Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, et al.
ACS Chem Neurosci
. 2023 Feb;
14(6):1080-1094.
PMID: 36812145
Glycogen synthase kinase 3 (GSK3) remains a therapeutic target of interest for diverse clinical indications. However, one hurdle in the development of small molecule GSK3 inhibitors has been safety concerns...
2.
Halkina T, Henderson J, Lin E, Himmelbauer M, Jones J, Nevalainen M, et al.
J Med Chem
. 2021 May;
64(9):6358-6380.
PMID: 33944571
Structural analysis of the known NIK inhibitor bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by...
3.
Nelson A, Calhoun M, Thomas A, Tavares J, Ferretti D, Dillon G, et al.
Front Cell Neurosci
. 2021 Jan;
14:566789.
PMID: 33424552
Ischemic stroke is recognized as one of the leading causes of adult disability, morbidity, and death worldwide. Following stroke, acute neuronal excitotoxicity can lead to many deleterious consequences, one of...
4.
Bao C, Bajrami B, Marcotte D, Chodaparambil J, Kerns H, Henderson J, et al.
Cell Mol Neurobiol
. 2020 May;
41(4):669-685.
PMID: 32424773
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging...
5.
Dillon G, Henderson J, Bao C, Joyce J, Calhoun M, Amaral B, et al.
PLoS One
. 2020 Apr;
15(4):e0228771.
PMID: 32255788
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to...
6.
Dillon G, Tyler W, Omuro K, Kambouris J, Tyminski C, Henry S, et al.
Neuron
. 2017 Mar;
93(6):1344-1358.e5.
PMID: 28285824
The Reelin signaling pathway plays a crucial role in regulating neocortical development. However, little is known about how Reelin controls the cytoskeleton during neuronal migration. Here, we identify CLASP2 as...
7.
Sullivan S, Dillon G, Sullivan J, Ho A
J Biol Chem
. 2014 Apr;
289(22):15374-83.
PMID: 24742670
Aberrant amyloid β (Aβ) production plays a causal role in Alzheimer disease pathogenesis. A major cellular pathway for Aβ generation is the activity-dependent endocytosis and proteolytic cleavage of the amyloid...
8.
Suidan G, Duerschmied D, Dillon G, VanderHorst V, Hampton T, Wong S, et al.
PLoS One
. 2013 Mar;
8(3):e59032.
PMID: 23516593
The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the...
9.
Beffert U, Dillon G, Sullivan J, Stuart C, Gilbert J, Kambouris J, et al.
J Neurosci
. 2012 Oct;
32(40):13906-16.
PMID: 23035100
Microtubule organization and dynamics are essential during axon and dendrite formation and maintenance in neurons. However, little is known about the regulation of microtubule dynamics during synaptic development and function...
10.
Dillon G, Lubbers L, Ferguson M, Lao J, Huang R, Xiao J, et al.
Behav Pharmacol
. 2011 Feb;
22(2):91-100.
PMID: 21301326
Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric disorders. In particular, the CB1R is highly...