Jean-Cosme Dodart
Overview
Explore the profile of Jean-Cosme Dodart including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1094
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Recent Articles
1.
Vroom M, Dodart J
Vaccines (Basel)
. 2024 Sep;
12(9).
PMID: 39340005
Neurodegenerative diseases (ND) give rise to significant declines in motor, autonomic, behavioral, and cognitive functions. Of these conditions, Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent, impacting...
2.
Eijsvogel P, Misra P, Concha-Marambio L, Boyd J, Ding S, Fedor L, et al.
Nat Med
. 2024 Jun;
30(9):2631-2640.
PMID: 38902546
Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson's disease (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center...
3.
Wang S, Guirakhoo F, Periasamy S, Ryan V, Wiggins J, Subramani C, et al.
Vaccines (Basel)
. 2024 Jan;
12(1).
PMID: 38250853
Antibodies provide critical protective immunity against COVID-19, and the Fc-mediated effector functions and mucosal antibodies also contribute to the protection. To expand the characterization of humoral immunity stimulated by subunit...
4.
Vroom M, Lu H, Lewis M, Thibodeaux B, Brooks J, Longo M, et al.
J Lipid Res
. 2024 Jan;
65(2):100497.
PMID: 38216056
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of disease burden in the world and is highly correlated with chronic elevations of LDL-C. LDL-C-lowering drugs, such as statins or monoclonal...
5.
Yu H, Dickson S, Wang P, Chiu M, Huang C, Chang C, et al.
EBioMedicine
. 2023 Jul;
94:104665.
PMID: 37392597
Background: Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing and treating Alzheimer's disease. UB-311 is an anti-amyloid-β active immunotherapeutic vaccine shown to be well-tolerated and to...
6.
Nimmo J, Verma A, Dodart J, Wang C, Savistchenko J, Melki R, et al.
Alzheimers Res Ther
. 2023 Jan;
15(1):18.
PMID: 36681823
No abstract available.
7.
Yu H, Thijssen E, van Brummelen E, van der Plas J, Radanovic I, Moerland M, et al.
Mov Disord
. 2022 Apr;
37(7):1416-1424.
PMID: 35426173
Background: α-Synuclein (αSyn) is believed to play a central role in Parkinson's disease (PD) neuropathology and is considered a target for disease modification. UB-312 is a synthetic αSyn peptide conjugated...
8.
Nimmo J, Smith H, Wang C, Teeling J, Nicoll J, Verma A, et al.
Acta Neuropathol
. 2021 Nov;
143(1):55-73.
PMID: 34741635
Alpha synuclein has a key role in the pathogenesis of Parkinson's disease (PD), Dementia with Lewy Bodies (LBD) and Multiple System Atrophy (MSA). Immunotherapies aiming at neutralising toxic αSyn species...
9.
Nimmo J, Kelly L, Verma A, Carare R, Nicoll J, Dodart J
Front Neurosci
. 2021 Sep;
15:733857.
PMID: 34539340
Alzheimer's disease and Lewy body diseases are the most common causes of neurodegeneration and dementia. Amyloid-beta (Aβ) and alpha-synuclein (αSyn) are two key proteins involved in the pathogenesis of these...
10.
Liu Y, Dodart J, Tran H, Berkovitch S, Braun M, Byrne M, et al.
Nat Commun
. 2021 Feb;
12(1):847.
PMID: 33558503
A large GC-repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuronal degeneration associated with this expansion arises from a...