Michael Calhoun
Overview
Explore the profile of Michael Calhoun including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
241
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Recent Articles
1.
Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, et al.
ACS Chem Neurosci
. 2023 Feb;
14(6):1080-1094.
PMID: 36812145
Glycogen synthase kinase 3 (GSK3) remains a therapeutic target of interest for diverse clinical indications. However, one hurdle in the development of small molecule GSK3 inhibitors has been safety concerns...
2.
Spencer E, Shi W, Komorowski R, Gilbert J, Ostrowski L, Bird L, et al.
Brain Commun
. 2022 May;
4(3):fcac106.
PMID: 35611307
Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited gene in neurons. Antisense oligonucleotide therapies are under development to reinstate UBE3A protein production. Non-invasive biomarkers to...
3.
Halkina T, Henderson J, Lin E, Himmelbauer M, Jones J, Nevalainen M, et al.
J Med Chem
. 2021 May;
64(9):6358-6380.
PMID: 33944571
Structural analysis of the known NIK inhibitor bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by...
4.
Autrusseau P, Labani A, De Marini P, Leyendecker P, Hintzpeter C, Ortlieb A, et al.
Diagn Interv Imaging
. 2021 Feb;
102(4):233-239.
PMID: 33583753
Purpose: The purpose of this study was to retrospectively evaluate the quantitative and qualitative intrapatient concordance of pulmonary nodule risk assessment by commercially available radiomics software between full-dose (FD) chest-CT...
5.
Dillon G, Henderson J, Bao C, Joyce J, Calhoun M, Amaral B, et al.
PLoS One
. 2020 Apr;
15(4):e0228771.
PMID: 32255788
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to...
6.
Grauer S, Sanoja R, Poulin D, Rashid H, Jochnowitz N, Calhoun M, et al.
Brain Res
. 2020 Apr;
1737:146814.
PMID: 32234514
Analgesic properties of orthosteric agonists of the muscarinic M receptor subtype have been documented in literature reports, with evidence from pharmacological and in vivo receptor knock out (KO) studies. Constitutive...
7.
Smith B, Arabandi S, Brochhausen M, Calhoun M, Ciccarese P, Doyle S, et al.
J Pathol Inform
. 2015 Jul;
6:37.
PMID: 26167381
Background: Ontology is one strategy for promoting interoperability of heterogeneous data through consistent tagging. An ontology is a controlled structured vocabulary consisting of general terms (such as "cell" or "image"...
8.
Heier C, Damsker J, Yu Q, Dillingham B, Huynh T, Van der Meulen J, et al.
EMBO Mol Med
. 2013 Sep;
5(10):1569-85.
PMID: 24014378
Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne muscular dystrophy (DMD). Current management by glucocorticoids has...
9.
Bondolfi L, Calhoun M, Ermini F, Kuhn H, Wiederhold K, Walker L, et al.
J Neurosci
. 2002 Jan;
22(2):515-22.
PMID: 11784797
APP23 transgenic mice express mutant human amyloid precursor protein and develop amyloid plaques predominantly in neocortex and hippocampus progressively with age, similar to Alzheimer's disease. We have previously reported neuron...