Thomas J Kornecook
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Explore the profile of Thomas J Kornecook including associated specialties, affiliations and a list of published articles.
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6
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58
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Recent Articles
1.
Murray J, Wu B, Tegley C, Nixey T, Falsey J, Herberich B, et al.
ACS Chem Biol
. 2019 Mar;
14(4):806-818.
PMID: 30875193
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel Na1.7, is being pursued to address the unmet medical need with respect to chronic...
2.
Wu B, Murray J, Andrews K, Sham K, Long J, Aral J, et al.
J Med Chem
. 2018 Oct;
61(21):9500-9512.
PMID: 30346167
Inhibitors of the voltage-gated sodium channel Na1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified Na1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula venom screens....
3.
La D, Peterson E, Bode C, Boezio A, Bregman H, Chu-Moyer M, et al.
Bioorg Med Chem Lett
. 2017 Jun;
27(15):3477-3485.
PMID: 28629594
The voltage-gated sodium channel Na1.7 has received much attention from the scientific community due to compelling human genetic data linking gain- and loss-of-function mutations to pain phenotypes. Despite this genetic...
4.
Kornecook T, Yin R, Altmann S, Be X, Berry V, Ilch C, et al.
J Pharmacol Exp Ther
. 2017 May;
362(1):146-160.
PMID: 28473457
Potent and selective antagonists of the voltage-gated sodium channel Na1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide...
5.
Dillon G, Lubbers L, Ferguson M, Lao J, Huang R, Xiao J, et al.
Behav Pharmacol
. 2011 Feb;
22(2):91-100.
PMID: 21301326
Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric disorders. In particular, the CB1R is highly...
6.
Dillon G, Shelton D, McKinney A, Caniga M, Marcus J, Ferguson M, et al.
Behav Brain Res
. 2009 May;
204(1):67-76.
PMID: 19416740
Sustained attention is defined as the ability or capacity to remain focused on the occurrence of rare events over long periods of time. We describe here the development of a...