Jacob N Marcus
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Explore the profile of Jacob N Marcus including associated specialties, affiliations and a list of published articles.
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17
Citations
1121
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Recent Articles
1.
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran H, Schirripa K, Roecker A, Breslin M, Tong L, Fillgrove K, et al.
ACS Med Chem Lett
. 2024 Jan;
15(1):123-131.
PMID: 38229758
Inhibition of glucosylceramide synthase (GCS) has been proposed as a therapeutic strategy for the treatment of Parkinson's Disease (PD), particularly in patients where glycosphingolipid accumulation and lysosomal impairment are thought...
2.
Roecker A, Schirripa K, Loughran H, Tong L, Liang T, Fillgrove K, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):146-155.
PMID: 36793422
Parkinson's disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Loss-of-function mutations in GBA, the gene that encodes for...
3.
Mahoney-Crane C, Viswanathan M, Russell D, Curtiss R, Freire J, Bobba S, et al.
J Neurosci
. 2023 Jan;
43(3):501-521.
PMID: 36639889
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutations , which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal...
4.
Zhang N, Hatcher N, Ekroos K, Kedia K, Kandebo M, Marcus J, et al.
J Lipid Res
. 2022 Apr;
63(6):100218.
PMID: 35489416
A major challenge of lipidomics is to determine and quantify the precise content of complex lipidomes to the exact lipid molecular species. Often, multiple methods are needed to achieve sufficient...
5.
Polinski N, Martinez T, Ramboz S, Sasner M, Herberth M, Switzer R, et al.
Dis Model Mech
. 2022 Apr;
15(6).
PMID: 35419585
Heterozygous mutations in the GBA1 gene - encoding lysosomal glucocerebrosidase (GCase) - are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased...
6.
Cosden M, Jinn S, Yao L, Gretzula C, Kandebo M, Toolan D, et al.
Neurobiol Dis
. 2021 Sep;
159:105507.
PMID: 34509608
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph)....
7.
Gentzel R, Toolan D, Jinn S, Schachter J, Ma L, Kahle P, et al.
Neurobiol Aging
. 2021 Jul;
106:12-25.
PMID: 34225000
Synucleinopathies are neurodegenerative disorders involving pathological alpha-synuclein (αSyn) protein, including dementia with Lewy bodies, multiple system atrophy and Parkinson's disease (PD). Current in vivo models of synucleinopathy include transgenic mice...
8.
Scott M, Marcus J, Pettersen A, Birnbaum S, Mochizuki T, Scammell T, et al.
Behav Brain Res
. 2011 Mar;
222(2):289-94.
PMID: 21377495
The orexin/hypocretin system has the potential to significantly modulate affect, based on both the neuroanatomical projection patterns of these neurons and on the sites of orexin receptor expression. However, there...
9.
Mochizuki T, Arrigoni E, Marcus J, Clark E, Yamamoto M, Honer M, et al.
Proc Natl Acad Sci U S A
. 2011 Mar;
108(11):4471-6.
PMID: 21368172
Narcolepsy is caused by a loss of orexin/hypocretin signaling, resulting in chronic sleepiness, fragmented non-rapid eye movement sleep, and cataplexy. To identify the neuronal circuits underlying narcolepsy, we produced a...
10.
Dillon G, Shelton D, McKinney A, Caniga M, Marcus J, Ferguson M, et al.
Behav Brain Res
. 2009 May;
204(1):67-76.
PMID: 19416740
Sustained attention is defined as the ability or capacity to remain focused on the occurrence of rare events over long periods of time. We describe here the development of a...