Giulio Superti-Furga
Overview
Explore the profile of Giulio Superti-Furga including associated specialties, affiliations and a list of published articles.
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Articles
238
Citations
18175
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Recent Articles
1.
Wang W, Garofoli A, Ferrada E, Klimek C, Steurer B, Ingles-Prieto A, et al.
Life Sci Alliance
. 2025 Jan;
8(4).
PMID: 39884836
The human () gene encodes a plasma membrane protein SLC39A8 (ZIP8) that mediates the specific uptake of the metals Cd, Mn, Zn, Fe, Co, and Se Pathogenic variants within are...
2.
Li H, Pike A, Chang Y, Prakaash D, Gelova Z, Stanka J, et al.
Nat Commun
. 2025 Jan;
16(1):721.
PMID: 39820269
Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects....
3.
Wolf G, Craigon C, Teoh S, Essletzbichler P, Onstein S, Cassidy D, et al.
Cell Chem Biol
. 2025 Jan;
32(2):291-306.e6.
PMID: 39755121
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable"...
4.
Kartnig F, Bonelli M, Goldmann U, Meszaros N, Krall N, Aletaha D, et al.
EBioMedicine
. 2024 Dec;
111():105522.
PMID: 39729885
Background: High content imaging-based functional precision medicine approaches have been developed and successfully applied in the field of haemato-oncology. For rheumatoid arthritis (RA), treatment selection is still based on a...
5.
Ferdigg A, Hopp A, Wolf G, Superti-Furga G
Life Sci Alliance
. 2024 Nov;
8(2).
PMID: 39578074
Non-essential metals are extremely toxic to living organisms, posing significant health risks, particularly in developing nations where they are a major contributor to illness and death. Although their toxicity is...
6.
Piech S, Bruschweiler S, Westphalen J, Siess K, Garcia Murias J, Konrat R, et al.
ACS Chem Biol
. 2024 Aug;
19(9):1942-1952.
PMID: 39194017
The RAS family of GTPases is among the most frequently mutated proteins in human cancer, creating a high clinical demand for therapies that counteract their signaling activity. An important layer...
7.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...
8.
Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, et al.
Nat Chem Biol
. 2024 Jun;
21(2):193-202.
PMID: 38907113
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product-inspired small molecules can provide a resource of invaluable chemotypes. Here, we...
9.
Gelova Z, Ingles-Prieto A, Bohstedt T, Frommelt F, Chi G, Chang Y, et al.
J Mol Biol
. 2024 Jun;
436(16):168665.
PMID: 38878854
Transporters of the solute carrier superfamily (SLCs) are responsible for the transmembrane traffic of the majority of chemical substances in cells and tissues and are therefore of fundamental biological importance....
10.
Azzollini L, Prete D, Wolf G, Klimek C, Saggioro M, Ricci F, et al.
SLAS Discov
. 2024 Jun;
29(5):100166.
PMID: 38848895
Zinc is an essential trace element that is involved in many biological processes and in cellular homeostasis. In pancreatic β-cells, zinc is crucial for the synthesis, processing, and secretion of...