Keiryn L Bennett
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Explore the profile of Keiryn L Bennett including associated specialties, affiliations and a list of published articles.
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114
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7529
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Recent Articles
1.
Austin S, Mekis R, Mohammed S, Scalise M, Wang W, Galluccio M, et al.
EMBO Rep
. 2022 Nov;
23(12):e54978.
PMID: 36321428
Mitochondrial Ca ions are crucial regulators of bioenergetics and cell death pathways. Mitochondrial Ca content and cytosolic Ca homeostasis strictly depend on Ca transporters. In recent decades, the major players...
2.
Lercher A, Bhattacharya A, Popa A, Caldera M, Schlapansky M, Baazim H, et al.
Immunity
. 2019 Dec;
51(6):1074-1087.e9.
PMID: 31784108
Infections induce complex host responses linked to antiviral defense, inflammation, and tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may orchestrate systemic metabolic changes...
3.
Sdelci S, Rendeiro A, Rathert P, You W, Lin J, Ringler A, et al.
Nat Genet
. 2019 May;
51(6):990-998.
PMID: 31133746
The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary...
4.
Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, et al.
Cancer Cell
. 2019 Jan;
35(1):125-139.e9.
PMID: 30645971
The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular underpinnings of this transmissible cancer, we combined pharmacological screens with...
5.
Szappanos D, Tschismarov R, Perlot T, Westermayer S, Fischer K, Platanitis E, et al.
PLoS Pathog
. 2018 Nov;
14(11):e1007397.
PMID: 30475900
DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms...
6.
Skucha A, Ebner J, Schmollerl J, Roth M, Eder T, Cesar-Razquin A, et al.
Nat Commun
. 2018 May;
9(1):1983.
PMID: 29777171
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical...
7.
Serwas N, Huemer J, Dieckmann R, Mejstrikova E, Garncarz W, Litzman J, et al.
Front Immunol
. 2018 Apr;
9:588.
PMID: 29651288
Specific granule deficiency (SGD) is a rare disorder characterized by abnormal neutrophils evidenced by reduced granules, absence of granule proteins, and atypical bilobed nuclei. Mutations in () are one molecular...
8.
Brown M, Johnson L, Leone D, Majek P, Vaahtomeri K, Senfter D, et al.
J Cell Biol
. 2018 Apr;
217(6):2205-2221.
PMID: 29650776
Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study, we report that LECs also release basolateral exosome-rich endothelial vesicles (EEVs) that are...
9.
Lee S, Song J, Bosl K, Muller A, Vitko D, Bennett K, et al.
Proteomics
. 2018 Feb;
18(8):e1700386.
PMID: 29474001
Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19 837 protein-coding genes have been annotated in the...
10.
Ishoey M, Chorn S, Singh N, Jaeger M, Brand M, Paulk J, et al.
ACS Chem Biol
. 2018 Jan;
13(3):553-560.
PMID: 29356495
Protein degradation is an emerging therapeutic strategy with a unique molecular pharmacology that enables the disruption of all functions associated with a target. This is particularly relevant for proteins depending...