Oliver Hantschel
Overview
Explore the profile of Oliver Hantschel including associated specialties, affiliations and a list of published articles.
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71
Citations
3189
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Recent Articles
1.
Schmidt N, Kumar A, Korf L, Dinh-Fricke A, Abendroth F, Koide A, et al.
Nat Commun
. 2024 Dec;
15(1):10724.
PMID: 39715735
Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis...
2.
Lebon C, Grossmann S, Mann G, Lindner F, Koide A, Koide S, et al.
Cell Commun Signal
. 2024 Oct;
22(1):500.
PMID: 39415233
Background: The inability of biologics to pass the plasma membrane prevents their development as therapeutics for intracellular targets. To address the lack of methods for cytosolic protein delivery, we used...
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Leyte-Vidal A, Ruiz D, DeFilippis R, Leske I, Rea D, Phan S, et al.
Blood
. 2024 Apr;
144(6):639-645.
PMID: 38643492
Secondary kinase domain mutations in BCR::ABL1 represent the most common cause of resistance to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia. The first 5 approved BCR::ABL1...
5.
Dinh-Fricke A, Hantschel O
Front Pharmacol
. 2024 Apr;
15.
PMID: 38617793
Cancer is a leading cause of death worldwide. Several targeted anticancer drugs entered clinical practice and improved survival of cancer patients with selected tumor types, but therapy resistance and metastatic...
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Schmidt N, Abendroth F, Vazquez O, Hantschel O
RSC Chem Biol
. 2022 Aug;
3(8):1008-1012.
PMID: 35975004
The d- and l-versions of the Bcr-Abl SH2 domain (12.7 kDa) were synthesized. Key optimizations included pseudoproline incorporation, -terminal hydrophilic tail addition and mild -acetoxy succinimide acetylation. Their folding and...
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Bittner Z, Liu X, Mateo Tortola M, Tapia-Abellan A, Shankar S, Andreeva L, et al.
J Exp Med
. 2021 Sep;
218(11).
PMID: 34554188
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that...
10.
Hatzopoulos G, Kukenshoner T, Banterle N, Favez T, Fluckiger I, Hamel V, et al.
Nat Commun
. 2021 Jun;
12(1):3805.
PMID: 34155202
Centrioles are evolutionarily conserved multi-protein organelles essential for forming cilia and centrosomes. Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a...