Gilbert Gallardo
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Explore the profile of Gilbert Gallardo including associated specialties, affiliations and a list of published articles.
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18
Citations
1704
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Recent Articles
1.
Mann C, Devi S, Kersting C, Bleem A, Karch C, Holtzman D, et al.
Sci Transl Med
. 2022 Feb;
14(632):eabm4107.
PMID: 35171651
Alzheimer's disease (AD) is the most dominant form of dementia characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tau tangles (NFTs). In addition to these pathologies, an...
2.
Gallardo G, Holtzman D
Adv Exp Med Biol
. 2020 Feb;
1184:187-203.
PMID: 32096039
Alzheimer's disease (AD) is the most common form of dementia characterized neuropathologically by senile plaques and neurofibrillary tangles (NFTs). Early breakthroughs in AD research led to the discovery of amyloid-β...
3.
Gallardo G, Wong C, Ricardez S, Mann C, Lin K, Leyns C, et al.
Mol Neurodegener
. 2019 Oct;
14(1):38.
PMID: 31640765
Background: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau...
4.
Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, et al.
J Clin Invest
. 2018 Mar;
128(5):2144-2155.
PMID: 29600961
The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in...
5.
Shi Y, Yamada K, Liddelow S, Smith S, Zhao L, Luo W, et al.
Nature
. 2017 Sep;
549(7673):523-527.
PMID: 28959956
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other...
6.
Ising C, Gallardo G, Leyns C, Wong C, Jiang H, Stewart F, et al.
J Exp Med
. 2017 May;
214(7):2163.
PMID: 28536241
No abstract available.
7.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Yanamandra K, Patel T, Jiang H, Schindler S, Ulrich J, Boxer A, et al.
Sci Transl Med
. 2017 Apr;
9(386).
PMID: 28424326
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies...
8.
Ising C, Gallardo G, Leyns C, Wong C, Jiang H, Stewart F, et al.
J Exp Med
. 2017 Apr;
214(5):1227-1238.
PMID: 28416651
Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological...
9.
Gallardo G, Holtzman D
Cold Spring Harb Perspect Med
. 2017 Jan;
7(10).
PMID: 28062555
The astonishing findings that active and passive immunization against amyloid-β (Aβ) in mouse models of Alzheimer's disease (AD) dramatically decreased amyloid burden led to a rapid initiation of human clinical...
10.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, et al.
J Neurosci
. 2015 Aug;
35(33):11514-31.
PMID: 26290230
Significance Statement: Degeneration of motor nerve terminals occurs in amyotrophic lateral sclerosis (ALS) patients as well as in mouse models of ALS, leading to progressive paralysis. What causes a motor...