Gerhard Grobner
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Explore the profile of Gerhard Grobner including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1059
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Recent Articles
1.
Altincekic N, Jores N, Lohr F, Richter C, Ehrhardt C, Blommers M, et al.
ACS Chem Biol
. 2024 Jan;
19(2):563-574.
PMID: 38232960
The main protease M, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four...
2.
Dudka I, Lundquist K, Wikstrom P, Bergh A, Grobner G
J Transl Med
. 2023 Nov;
21(1):860.
PMID: 38012666
Background: Prostate cancer (PC) is a heterogenous multifocal disease ranging from indolent to lethal states. For improved treatment-stratification, reliable approaches are needed to faithfully differentiate between high- and low-risk tumors...
3.
Clifton L, Wacklin-Knecht H, Aden J, Mushtaq A, Sparrman T, Grobner G
Sci Adv
. 2023 Jun;
9(22):eadg7940.
PMID: 37267355
Apotosis is an essential process tightly regulated by the Bcl-2 protein family where proapoptotic Bax triggers cell death by perforating the mitochondrial outer membrane. Although intensively studied, the molecular mechanism...
4.
Mushtaq A, Aden J, Ali K, Grobner G
Biophys J
. 2022 Nov;
121(23):4517-4525.
PMID: 36325615
Programmed mammalian cell death (apoptosis) is an essential mechanism in life that tightly regulates embryogenesis and removal of dysfunctional cells. In its intrinsic (mitochondrial) pathway, opposing members of the Bcl-2...
5.
Yu J, Yao M, Grobner G, Sundqvist B, Tonpheng B, Liu B, et al.
ACS Macro Lett
. 2022 May;
2(6):511-517.
PMID: 35581808
A Buckminsterfullerene/polyisoprene (C/PI) composite was synthesized at high-temperature, high-pressure (HP&HT) conditions. The composite has significantly improved tensile strength and Young's modulus, by up to 49% and 88% per wt %...
6.
Nadeem A, Berg A, Pace H, Alam A, Toh E, Aden J, et al.
Elife
. 2022 Feb;
11.
PMID: 35131030
The α-pore-forming toxins (α-PFTs) from pathogenic bacteria damage host cell membranes by pore formation. We demonstrate a remarkable, hitherto unknown mechanism by an α-PFT protein from . As part of...
7.
Mushtaq A, Aden J, Alam A, Sjostedt A, Grobner G
Biomol NMR Assign
. 2022 Jan;
16(1):75-79.
PMID: 34985724
The Hsp100 family member ClpB is a protein disaggregase which solubilizes and reactivates stress-induced protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. In the pathogenic bacterium Francisella tularensis, ClpB...
8.
Mushtaq A, Aden J, Clifton L, Wacklin-Knecht H, Campana M, Dingeldein A, et al.
Commun Biol
. 2021 Apr;
4(1):507.
PMID: 33907308
B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic tail-anchor enabling them to translocate to their target membrane and to shift...
9.
Fohringer C, Dudka I, Spitzer R, Stenbacka F, Rzhepishevska O, Cromsigt J, et al.
Ecol Evol
. 2021 Apr;
11(7):3159-3183.
PMID: 33841775
With accelerated land conversion and global heating at northern latitudes, it becomes crucial to understand, how life histories of animals in extreme environments adapt to these changes. Animals may either...
10.
Mushtaq A, Aden J, Sparrman T, Hedenstrom M, Grobner G
Molecules
. 2021 Apr;
26(5).
PMID: 33800399
Evasion from programmed cell death (apoptosis) is the main hallmark of cancer and a major cause of resistance to therapy. Many tumors simply ensure survival by over-expressing the cell-protecting (anti-apoptotic)...