Ameeq Ul Mushtaq
Overview
Explore the profile of Ameeq Ul Mushtaq including associated specialties, affiliations and a list of published articles.
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20
Citations
141
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Recent Articles
1.
Jonsson M, Mushtaq A, Nagy T, von Witting E, Lofblom J, Nam K, et al.
J Biol Chem
. 2024 Sep;
300(11):107795.
PMID: 39305954
Designing proteins with tunable activities from easily accessible external cues remains a biotechnological challenge. Here, we set out to create a small antibody-binding domain equipped with a molecular switch inspired...
2.
Clifton L, Wacklin-Knecht H, Aden J, Mushtaq A, Sparrman T, Grobner G
Sci Adv
. 2023 Jun;
9(22):eadg7940.
PMID: 37267355
Apotosis is an essential process tightly regulated by the Bcl-2 protein family where proapoptotic Bax triggers cell death by perforating the mitochondrial outer membrane. Although intensively studied, the molecular mechanism...
3.
Verma A, Aberg-Zingmark E, Sparrman T, Mushtaq A, Rogne P, Grundstrom C, et al.
Sci Adv
. 2022 Nov;
8(44):eabm4089.
PMID: 36332013
Enzymatic catalysis is critically dependent on selectivity, active site architecture, and dynamics. To contribute insights into the interplay of these properties, we established an approach with NMR, crystallography, and MD...
4.
Mushtaq A, Aden J, Ali K, Grobner G
Biophys J
. 2022 Nov;
121(23):4517-4525.
PMID: 36325615
Programmed mammalian cell death (apoptosis) is an essential mechanism in life that tightly regulates embryogenesis and removal of dysfunctional cells. In its intrinsic (mitochondrial) pathway, opposing members of the Bcl-2...
5.
Kim D, Choi Y, Lee Y, Lim S, Kong J, Song J, et al.
Nat Commun
. 2022 May;
13(1):2572.
PMID: 35546148
Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest to control KRAS-driven cancers. Here, we report that AIMP2-DX2,...
6.
Mushtaq A, Aden J, Alam A, Sjostedt A, Grobner G
Biomol NMR Assign
. 2022 Jan;
16(1):75-79.
PMID: 34985724
The Hsp100 family member ClpB is a protein disaggregase which solubilizes and reactivates stress-induced protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. In the pathogenic bacterium Francisella tularensis, ClpB...
7.
Phoeurk C, Mushtaq A, Rogne P, Wolf-Watz M
Protein Expr Purif
. 2021 May;
186:105919.
PMID: 34044132
Silk is one of the most versatile biomaterials with signature properties of outstanding mechanical strength and flexibility. A potential avenue for developing more environmentally friendly silk production is to make...
8.
Mushtaq A, Aden J, Clifton L, Wacklin-Knecht H, Campana M, Dingeldein A, et al.
Commun Biol
. 2021 Apr;
4(1):507.
PMID: 33907308
B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic tail-anchor enabling them to translocate to their target membrane and to shift...
9.
Mushtaq A, Aden J, Sparrman T, Hedenstrom M, Grobner G
Molecules
. 2021 Apr;
26(5).
PMID: 33800399
Evasion from programmed cell death (apoptosis) is the main hallmark of cancer and a major cause of resistance to therapy. Many tumors simply ensure survival by over-expressing the cell-protecting (anti-apoptotic)...
10.
Aden J, Mushtaq A, Dingeldein A, Wallgren M, Grobner G
Protein Expr Purif
. 2020 Mar;
172:105628.
PMID: 32209420
Programmed cell death (apoptosis) is an essential mechanism in life that tightly regulates embryogenesis and removal of harmful cells. Besides an extrinsic pathway, an intrinsic (mitochondrial) apoptotic pathway exists where...